(5R,8R,10R)-6-Methyl-8-(1H-pyrazol-1-ylmethyl)ergoline

Base Information

Chemical Name:(5R,8R,10R)-6-Methyl-8-(1H-pyrazol-1-ylmethyl)ergoline
CAS No.:105579-45-1
Molecular Formula:C₁₉H₂₂N₄
Molecular Weight:306.41
Hs Code.:
DSSTox Substance ID:DTXSID20909602

Synonyms:6-Methyl-8-beta-((1H-pyrazol-1-yl)methyl)ergoline;(5R,8R,10R)-6-Methyl-8-(1H-pyrazol-1-ylmethyl)ergoline;Ergoline, 6-methyl-8-((H-pyrazol-1-yl)methyl)-, (8-beta)-;105579-45-1;SCHEMBL10757665;DTXSID20909602;LS-64475;6-Methyl-8-[(1H-pyrazol-1-yl)methyl]ergoline

Suppliers and Price of (5R,8R,10R)-6-Methyl-8-(1H-pyrazol-1-ylmethyl)ergoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of (5R,8R,10R)-6-Methyl-8-(1H-pyrazol-1-ylmethyl)ergoline

Chemical Property:

Vapor Pressure:7.61E-11mmHg at 25°C
Boiling Point:518.3°Cat760mmHg
Flash Point:267.2°C
Density:1.35g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:306.18444672
Heavy Atom Count:23
Complexity:441

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1CC(CC2C1CC3=CNC4=CC=CC2=C34)CN5C=CC=N5
Isomeric SMILES:CN1C[C@@H](CC2[C@H]1CC3=CNC4=CC=CC2=C34)CN5C=CC=N5

Technology Process of (5R,8R,10R)-6-Methyl-8-(1H-pyrazol-1-ylmethyl)ergoline

There total 5 articles about (5R,8R,10R)-6-Methyl-8-(1H-pyrazol-1-ylmethyl)ergoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58752-31-1
6-methyl-8β-tosyloxymethyl-ergoline

: 105579-45-1
(5R,8R,10R)-6-methyl-8-(1-pyrazolylmethyl)ergoline

Guidance literature:: With NH-pyrazole; In N-methyl-acetamide; water;

Reference yield:

: 5878-43-3
9,10-dihydrolysergic acid

: 105579-45-1
(5R,8R,10R)-6-methyl-8-(1-pyrazolylmethyl)ergoline

Guidance literature:: Multi-step reaction with 4 steps

1: H₂SO₄

2: 82 percent / aq. NaBH₄ / methanol / 2 h / Heating

3: 80 percent / pyridine / 3 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 2.) DMF, 90 deg C, 1 h

With pyridine; sodium tetrahydroborate; sulfuric acid; sodium hydride; In methanol;
DOI:10.1248/cpb.42.1463

Reference yield:

: 3006-19-7,5143-94-2,35470-53-2,77842-02-5,87247-99-2,96648-31-6,96648-32-7
9,10-dihydrolysergic acid methyl ester

: 105579-45-1
(5R,8R,10R)-6-methyl-8-(1-pyrazolylmethyl)ergoline

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / aq. NaBH₄ / methanol / 2 h / Heating

2: 80 percent / pyridine / 3 h / Ambient temperature

3: 1.) NaH / 1.) DMF, 2.) DMF, 90 deg C, 1 h

With pyridine; sodium tetrahydroborate; sodium hydride; In methanol;
DOI:10.1248/cpb.42.1463