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Technology Process of Colistin

Colistin

Base Information
  • Chemical Name:Colistin
  • CAS No.:1066-17-7
  • Molecular Formula:C52H98N16O13
  • Molecular Weight:968.43
  • Hs Code.:
  • European Community (EC) Number:213-907-3
  • Wikipedia:Colistin
  • Wikidata:Q73589871
  • NCI Thesaurus Code:C65350
  • RXCUI:2709
  • Metabolomics Workbench ID:43094
  • ChEMBL ID:CHEMBL499783
Colistin

Synonyms:Colimycin;Colisticin;Colistin;Colistin Sulfate;Coly-Mycin;Polymyxin E;Sulfate, Colistin;Totazina

Suppliers and Price of Colistin
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Sigma-Aldrich
  • Colistin for system suitability European Pharmacopoeia (EP) Reference Standard
  • $ 128.90
  • Sigma-Aldrich
  • Colistin for system suitability European Pharmacopoeia (EP) Reference Standard
  • y0001999
  • $ 128.90
  • Cayman Chemical
  • Colistin ≥95%
  • 25mg
  • $ 89.00
  • Cayman Chemical
  • Colistin ≥95%
  • 100mg
  • $ 285.00
  • AK Scientific
  • Colistin
  • 100mg
  • $ 484.00
  • AK Scientific
  • Colistin
  • 25mg
  • $ 220.00
Total 50 raw suppliers
Chemical Property of Colistin
Chemical Property:
  • Vapor Pressure:0mmHg at 25°C 
  • Refractive Index:1.573 
  • Boiling Point:1536.8°Cat760mmHg 
  • Flash Point:883.3°C 
  • PSA：490.66000 
  • Density:1.25g/cm3 
  • LogP:1.53520 
  • XLogP3:-3.3
  • Hydrogen Bond Donor Count:18
  • Hydrogen Bond Acceptor Count:18
  • Rotatable Bond Count:28
  • Exact Mass:1154.74992724
  • Heavy Atom Count:81
  • Complexity:2050
Purity/Quality:

99% *data from raw suppliers

Colistin for system suitability European Pharmacopoeia (EP) Reference Standard *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Other Uses -> Pharmaceuticals
  • Canonical SMILES:CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O
  • Isomeric SMILES:CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O
  • Recent ClinicalTrials:IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy
  • Recent EU Clinical Trials:Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa
  • Recent NIPH Clinical Trials:An evaluation of the efficacy and safety of colistimethate sodium injection in patients with multidrug-resistant Gram-negative bacterial infection - A multicenter, unblinded clinical study -
  • General Description Colistin, also known as Polymyxin E, is a last-resort antibiotic used to treat infections caused by multidrug-resistant Gram-negative bacteria. However, its efficacy is increasingly threatened by the emergence of the mcr-1 gene, which confers resistance to colistin. Research has identified novel MCR-1 inhibitors, such as 1-phenyl-2-(phenylamino)ethanone derivatives, which can restore colistin's activity by targeting and inhibiting the MCR-1 enzyme. These findings underscore the importance of developing adjunct therapies to counteract colistin resistance and preserve its clinical utility.
Refernces

Design, synthesis and biological evaluation of 1-Phenyl-2-(phenylamino) Ethanone Derivatives as Novel MCR-1 Inhibitors

10.3390/molecules24152719

This research focuses on the design, synthesis, and biological evaluation of 1-phenyl-2-(phenylamino)ethanone derivatives as novel MCR-1 inhibitors to combat colistin resistance caused by the mcr-1 gene. The study identified racemic compound 3 as a potential MCR-1 inhibitor through virtual screening, and subsequently, 26 derivatives were synthesized and evaluated for their inhibitory activity. The most potent compounds, 6p and 6q, were found to effectively inhibit the growth of E. coli BL21(DE3) expressing mcr-1 when combined with colistin. These compounds were also shown to inhibit the enzymatic activity of MCR-1 in vitro. Molecular docking studies revealed that the active compounds interact with key amino acids in the MCR-1 protein, providing insights into their mechanism of action. The research highlights the potential of these compounds as a strategy to overcome colistin resistance and suggests further optimization and development of MCR-1 inhibitors.

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