Colistin

Base Information

• Chemical Name: Colistin
• CAS No.: 1066-17-7
• Molecular Formula: C52H98N16O13
• Molecular Weight: 968.43
• European Community (EC) Number: 213-907-3
• Wikipedia: Colistin
• Wikidata: Q73589871
• NCI Thesaurus Code: C65350
• RXCUI: 2709
• Metabolomics Workbench ID: 43094
• ChEMBL ID: CHEMBL499783
• Mol file: 1066-17-7.mol

Synonyms:Colimycin;Colisticin;Colistin;Colistin Sulfate;Coly-Mycin;Polymyxin E;Sulfate, Colistin;Totazina

Chemical Property of Colistin

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.573
• Boiling Point: 1536.8°Cat760mmHg
• Flash Point: 883.3°C
• PSA: 490.66000
• Density: 1.25g/cm³
• LogP: 1.53520
• XLogP3: -3.3
• Hydrogen Bond Donor Count: 18
• Hydrogen Bond Acceptor Count: 18
• Rotatable Bond Count: 28
• Exact Mass: 1154.74992724
• Heavy Atom Count: 81
• Complexity: 2050

Purity/Quality:

99% ^*data from raw suppliers

Colistin for system suitability European Pharmacopoeia (EP) Reference Standard ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Pharmaceuticals
• Canonical SMILES: CCC(C)CCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)C(C)O
• Isomeric SMILES: CCC(C)CCCC(=O)N[C@@H](CCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCN)C(=O)N[C@H]1CCNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCN)CC(C)C)CC(C)C)CCN)CCN)[C@@H](C)O
• Recent ClinicalTrials: IV Colistin for Pulmonary Exacerbations: Improving Safety and Efficacy
• Recent EU Clinical Trials: Efficacy and safety of 7 versus 14 days of antibiotic treatment for Pseudomonas aeruginosa
• Recent NIPH Clinical Trials: An evaluation of the efficacy and safety of colistimethate sodium injection in patients with multidrug-resistant Gram-negative bacterial infection - A multicenter, unblinded clinical study -
• Uses: Polymyxin E (colistin) is a complex of closely related cyclic peptides E1 and E2, with additional minor analogues. Polymyxin E is produced by Bacillus polymyxa var. colistinus, and is a highly basic, atypical cyclic peptide which incorporates the unusual amino acid, diaminobutyric acid. Head-to-tail coupling of lysine completes the macrocycle. Balancing the polar cyclic peptide is a hydrophobic tail with short chain fatty acids. Polymyxin E is a broad spectrum antibiotic active against Gram negative bacteria. The mechanism of action involves disruption of the bacterial outer membrane by a detergent-like effect.