2,4,5-trihydroxyamphetamine

Base Information

• Chemical Name: 2,4,5-trihydroxyamphetamine
• CAS No.: 136706-33-7
• Molecular Formula: C₉H₁₃NO₃
• Molecular Weight: 183.207
• Mol file: 136706-33-7.mol

Synonyms:2,4,5-Trihydroxyamphetamine;a-Methyl-2,4,5-trihydroxyphenethylamine;a-Methyl-6-hydroxydopamine

Chemical Property of 2,4,5-trihydroxyamphetamine

Chemical Property:

• Vapor Pressure: 5.9E-07mmHg at 25°C
• Boiling Point: 399.5°Cat760mmHg
• Flash Point: 195.4°C
• Density: 1.326g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4,5-trihydroxyamphetamine

There total 4 articles about 2,4,5-trihydroxyamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.2%

α-methyldopamine (555-64-6,14513-20-3) → 1H-indole-5,6-diol (3131-52-0) + 1-(2,4,5-trihydroxyphenyl)-2-aminopropane (41241-36-5,136706-33-7) + 6-nitrodopamine

Guidance literature:

With dihydrogen peroxide; horseradish peroxidase; sodium nitrite; In phosphate buffer; at 37 ℃; pH=7.4; Further Variations:; pH-values; Reagents; Product distribution; Kinetics;

DOI:10.1021/tx990121g

Reference yield:

asaraldehyde (4460-86-0,14374-62-0) → 1-(2,4,5-trihydroxyphenyl)-2-aminopropane (41241-36-5,136706-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: NH₄OAc / acetic acid

2: (i) LiAlH₄, Et₂O, (ii) BBr₃, CH₂Cl₂

With ammonium acetate; In acetic acid;

DOI:10.1021/jm00232a007

Reference yield:

2,4,5-trimethoxy-β-methyl-β-nitrostyrene (134040-35-0,17231-84-4) → 1-(2,4,5-trihydroxyphenyl)-2-aminopropane (41241-36-5,136706-33-7)

Guidance literature:

Multistep reaction; (i) LiAlH₄, Et₂O, (ii) BBr₃, CH₂Cl₂;

DOI:10.1021/jm00232a007

upstream raw materials:

2,4,5-trimethoxy-β-methyl-β-nitrostyrene

α-methyldopamine

asaraldehyde