4-propylaminoglutethimide

Base Information

• Chemical Name: 4-propylaminoglutethimide
• CAS No.: 110977-60-1
• Molecular Formula: C₁₆H₂₂N₂O₂
• Molecular Weight: 274.363
• Mol file: 110977-60-1.mol

Synonyms:4-propylaminoglutethimide

Chemical Property of 4-propylaminoglutethimide

Chemical Property:

• Vapor Pressure: 3.53E-09mmHg at 25°C
• Boiling Point: 474.7°Cat760mmHg
• Flash Point: 240.9°C
• PSA: 75.68000
• Density: 1.088g/cm³
• LogP: 3.23650

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-propylaminoglutethimide

There total 6 articles about 4-propylaminoglutethimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Ethyl-3-(4-nitro-phenyl)-4-propyl-piperidine-2,6-dione → 3-(4-Amino-phenyl)-3-ethyl-4-propyl-piperidine-2,6-dione (110977-60-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; Yield given;

DOI:10.1002/ardp.19873200109

Reference yield:

2-phenylbutanenitrile (769-68-6) → 3-(4-Amino-phenyl)-3-ethyl-4-propyl-piperidine-2,6-dione (110977-60-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 42 percent / Triton B / methanol; dioxane / 15 h / Heating

2: NaOH / aq. ethanol; tetrahydrofuran / 3 h

3: polyphosphoric acid / 3 h / 130 - 140 °C

4: conc. H₂SO₄, HNO₃ / 2 h / -10 - 0 °C

5: H₂ / 10percent Pd/C / ethanol

With sodium hydroxide; PPA; sulfuric acid; hydrogen; nitric acid; N-benzyl-trimethylammonium hydroxide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;

DOI:10.1002/ardp.19873200109

Reference yield:

phenylacetonitrile (140-29-4) → 3-(4-Amino-phenyl)-3-ethyl-4-propyl-piperidine-2,6-dione (110977-60-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 74 percent / NaNH₂ / benzene / 1 h / 80 °C

2: 42 percent / Triton B / methanol; dioxane / 15 h / Heating

3: NaOH / aq. ethanol; tetrahydrofuran / 3 h

4: polyphosphoric acid / 3 h / 130 - 140 °C

5: conc. H₂SO₄, HNO₃ / 2 h / -10 - 0 °C

6: H₂ / 10percent Pd/C / ethanol

With sodium hydroxide; PPA; sulfuric acid; hydrogen; nitric acid; N-benzyl-trimethylammonium hydroxide; sodium amide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; benzene;

DOI:10.1002/ardp.19873200109

upstream raw materials:

2-phenylbutanenitrile

phenylacetonitrile

Refernces