(R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoic acid

Base Information

Chemical Name:(R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoic acid
CAS No.:6306-53-2
Molecular Formula:C₁₃H₁₃NO₄
Molecular Weight:247.251
Hs Code.:
NSC Number:22911
DSSTox Substance ID:DTXSID801152470
Nikkaji Number:J1.282.772E

Synonyms:6306-53-2;(R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoic acid;N,N-PHTHALOYL-D-VALINE;SCHEMBL1171070;DTXSID801152470;NSC22911;NSC-22911;AT22567;(R)-2-Phthalimidyl-3-methylbutanoic acid;(R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoicacid;(2R)-2-(1,3-Dioxoisoindolin-2-yl)-3-methylbutanoic acid;(alphaR)-1,3-Dihydro-alpha-(1-methylethyl)-1,3-dioxo-2H-isoindole-2-acetic acid

Suppliers and Price of (R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 7 raw suppliers

Chemical Property of (R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoic acid

Chemical Property:

Vapor Pressure:1.11E-07mmHg at 25°C
Boiling Point:416.5°Cat760mmHg
Flash Point:205.7°C
Density:1.353g/cm³
XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:247.08445790
Heavy Atom Count:18
Complexity:367

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)O)N1C(=O)C2=CC=CC=C2C1=O
Isomeric SMILES:CC(C)[C@H](C(=O)O)N1C(=O)C2=CC=CC=C2C1=O

Technology Process of (R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoic acid

There total 6 articles about (R)-2-(1,3-dioxoisoindolin-2-yl)-3-methylbutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 85-44-9
phthalic anhydride

: 640-68-6,25609-85-2,7004-03-7,921-10-8
D-Val-OH

: 5115-65-1,6306-53-2,6306-54-3,19506-85-5
(R)-N-phthaloylvaline

Guidance literature:: With triethylamine; In toluene; Heating;
DOI:10.1016/j.tet.2005.07.049

Reference yield: 78.0%

: 85-44-9
phthalic anhydride

: 516-06-3,25609-85-2,7004-03-7,921-10-8
D,L-valine

: 5115-65-1,6306-53-2,6306-54-3,19506-85-5
N-phthaloyl-DL-valine

Guidance literature:: at 100 ℃; for 1h;

Reference yield:

: 1242459-41-1
C₁₉H₂₉NO₄Si₂

: 5115-65-1,6306-53-2,6306-54-3,19506-85-5
(R)-N-phthaloylvaline

: 6306-54-3
N-phthaloyl L-valine

Guidance literature:: With 2,6-di-tert-butyl-pyridine; 2.6-dimethylphenol; C₃₂H₁₂BF₂₄^(1-)*C₄₄H₃₀N₂O₂P⁽¹⁺⁾; In toluene; at 20 ℃; for 2h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja105945z