alpha-Hydroxyetizolam

Base Information

Chemical Name:alpha-Hydroxyetizolam
CAS No.:64546-10-7
Molecular Formula:C17H15 Cl N4 O S
Molecular Weight:358.851
Hs Code.:
UNII:AYC2I7NE1D
Nikkaji Number:J1.924.226I
Wikidata:Q27274187
Wikipedia:Alpha-Hydroxyetizolam

Synonyms:6-(2-chlorophenyl)-8-(1-hydroxyethyl)-1-methyl-4-triazolo-3,4-thieno-(2,3-e)(1,4) diazepine;alpha-hydroxyetizolam

Suppliers and Price of alpha-Hydroxyetizolam

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ALPHA-HYDROXY ETIZOLAM 95.00%
5MG
$ 501.72

Total 2 raw suppliers

Chemical Property of alpha-Hydroxyetizolam

Chemical Property:

Vapor Pressure:7.35E-16mmHg at 25°C
Boiling Point:612.6°C at 760 mmHg
PKA:13.52±0.20(Predicted)
Flash Point:324.3°C
PSA：91.54000
Density:1.51g/cm³
LogP:3.13050
XLogP3:1.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:358.0655100
Heavy Atom Count:24
Complexity:507

Purity/Quality:

98% ^*data from raw suppliers

ALPHA-HYDROXY ETIZOLAM 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NN=C2N1C3=C(C=C(S3)C(C)O)C(=NC2)C4=CC=CC=C4Cl
Uses alpha-hydroxyetizolam is a metabolite of Brotizolam (B689280). A hypnotic and a sedative, also used in veterinary medicine as an appetite stimulant.

Technology Process of alpha-Hydroxyetizolam

There total 5 articles about alpha-Hydroxyetizolam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5000-66-8
2-chlorophenacyl bromide

: 64546-10-7
1-[7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0²,⁶]trideca-2⁽⁶⁾,4,7,10,12-pentaen-4-yl]ethan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: dimethyl sulfoxide

2.1: sulfur; triethylamine / N,N-dimethyl-formamide / 4 h / 20 °C

3.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

4.1: hydrazine hydrate / ethanol / 2.5 h / Reflux

4.2: 30 h / Reflux

5.1: sodium hydrogencarbonate; tetraphosphorus decasulfide / diethylene glycol dimethyl ether / 2 h / 80 °C

5.2: 1 h / 20 °C

5.3: 18 h / 20 °C

With sulfur; tetraphosphorus decasulfide; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; diethylene glycol dimethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; 2.1: |Gewald Aminoheterocycles Synthesis;
DOI:10.1016/j.chempr.2018.02.002

Reference yield:

: C₂₁H₂₇ClN₂O₂SSi

: 78-39-7
Triethyl orthoacetate

: 64546-10-7
1-[7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0²,⁶]trideca-2⁽⁶⁾,4,7,10,12-pentaen-4-yl]ethan-1-ol

Guidance literature:: C₂₁H₂₇ClN₂O₂SSi; With tetraphosphorus decasulfide; sodium hydrogencarbonate; In diethylene glycol dimethyl ether; at 80 ℃; for 2h;

With hydrazine hydrate; In ethanol; at 20 ℃; for 1h;

Triethyl orthoacetate; With sulfuric acid; In ethanol; toluene; at 20 ℃; for 18h;
DOI:10.1016/j.chempr.2018.02.002

Reference yield:

: 5-{1-[(tert-butyldimethylsilyl)oxy]ethyl}-3-(2-chlorobenzoyl)thiophen-2-amine

: 64546-10-7
1-[7-(2-chlorophenyl)-13-methyl-3-thia-1,8,11,12-tetraazatricyclo[8.3.0.0²,⁶]trideca-2⁽⁶⁾,4,7,10,12-pentaen-4-yl]ethan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2.1: hydrazine hydrate / ethanol / 2.5 h / Reflux

2.2: 30 h / Reflux

3.1: sodium hydrogencarbonate; tetraphosphorus decasulfide / diethylene glycol dimethyl ether / 2 h / 80 °C

3.2: 1 h / 20 °C

3.3: 18 h / 20 °C

With tetraphosphorus decasulfide; sodium hydrogencarbonate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane; diethylene glycol dimethyl ether;
DOI:10.1016/j.chempr.2018.02.002