3-(4-Fluorophenacyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione

Base Information

Chemical Name:3-(4-Fluorophenacyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione
CAS No.:151956-06-8
Molecular Formula:C₁₈H₁₁ClFNO₃S
Molecular Weight:375.808
Hs Code.:
Nikkaji Number:J598.656G
Wikidata:Q76389338
Mol file:151956-06-8.mol

Synonyms:3-(4-Fluorophenacyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione;2,4-Thiazolidinedione, 5-((2-chlorophenyl)methylene)-3-(2-(4-fluorophenyl)-2-oxoethyl)-;5-((2-Chlorophenyl)methylene)-3-(2-(4-fluorophenyl)-2-oxoethyl)-2,4-thiazolidinedione;151956-06-8;C18H11ClFNO3S;LS-151300;3-(4-Fluoro-beta-oxophenethyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione

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Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-Fluorophenacyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione

Chemical Property:

Vapor Pressure:4.17E-12mmHg at 25°C
Boiling Point:549.1°Cat760mmHg
Flash Point:285.9°C
Density:1.484g/cm³
XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:375.0132202
Heavy Atom Count:25
Complexity:589

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C=C2C(=O)N(C(=O)S2)CC(=O)C3=CC=C(C=C3)F)Cl
Isomeric SMILES:C1=CC=C(C(=C1)/C=C\2/C(=O)N(C(=O)S2)CC(=O)C3=CC=C(C=C3)F)Cl

Technology Process of 3-(4-Fluorophenacyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione

There total 2 articles about 3-(4-Fluorophenacyl)-5-(2-chlorobenzylidene)thiazolidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 89-98-5
2-chloro-benzaldehyde

: 870554-59-9
3-[2-(4-fluorophenyl)-2-oxo-ethyl]thiazolidine-2,4-dione

: 151956-06-8
N-(4'-fluorophenacyl)-5-(2-chlorobenzylidene)-thiazolidine-2,4-dione

Guidance literature:: With sodium acetate; In acetic acid; at 140 - 150 ℃;

Reference yield:

: 456-04-2
2-Chloro-4'-fluoroacetophenone

: 151956-06-8
N-(4'-fluorophenacyl)-5-(2-chlorobenzylidene)-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) potassium hydroxide / 1.) MeOH, 10 min, 2.) MeOH, reflux, 1 h

2: 62 percent / sodium acetate / acetic acid / 140 - 150 °C

With potassium hydroxide; sodium acetate; In acetic acid;