2,7-Diamino-1-hydroxymitosene

Base Information

• Chemical Name: 2,7-Diamino-1-hydroxymitosene
• CAS No.: 1096-49-7
• Molecular Formula: C₁₄H₁₆N₄O₅
• Molecular Weight: 320.305
• DSSTox Substance ID: DTXSID30911256
• Nikkaji Number: J72.942F
• ChEMBL ID: CHEMBL41917
• Mol file: 1096-49-7.mol

Synonyms:(Mixture cis/trans);1-Hydroxy-2,7-diamino Mitosene;cis-1-Hydroxy-2,7-diaminoMitosene;trans-1-Hydroxy-2,7-diaminoMitosene;98462-75-0;1096-49-7;2,7-Diamino-1-hydroxymitosene;99745-88-7;BRN 0498310;CHEMBL41917;DTXSID30911256;(2,6-diamino-3-hydroxy-7-methyl-5,8-dioxo-2,3-dihydro-1H-pyrrolo[1,2-a]indol-4-yl)methyl carbamate;1H-Pyrrolo(1,2-a)indole-5,8-dione, 2,3-dihydro-2,7-diamino-1-hydroxy-9-(hydroxymethyl)-6-methyl-, 9-carbamate;FT-0669530;(2,7-Diamino-1-hydroxy-6-methyl-5,8-dioxo-2,3,5,8-tetrahydro-1H-pyrrolo[1,2-a]indol-9-yl)methyl hydrogen carbonimidate

Chemical Property of 2,7-Diamino-1-hydroxymitosene

Chemical Property:

• Vapor Pressure: 2.06E-13mmHg at 25°C
• Boiling Point: 560.8°Cat760mmHg
• Flash Point: 293°C
• Density: 1.9g/cm³
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 3
• Exact Mass: 320.11206962
• Heavy Atom Count: 23
• Complexity: 618

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=C(C(=O)C2=C(C1=O)N3CC(C(C3=C2COC(=O)N)O)N)N

Technology Process of 2,7-Diamino-1-hydroxymitosene

There total 4 articles about 2,7-Diamino-1-hydroxymitosene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,7-diamino-1-hydroxymitosene 1-uridilate (114612-47-4) → 1-Hydroxy-2,7-diaminomitosen (1096-49-7,102679-60-7,102679-61-8,78655-54-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In water; for 0.5h;

DOI:10.1021/jm00403a016

Reference yield:

mitomycin C (50-07-7) → 1-Hydroxy-2,7-diaminomitosen (1096-49-7,102679-60-7,102679-61-8,78655-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 21 percent / dimethylformamide / 50 - 60 °C

2: hydrogen / 10percent palladium-on-charcoal / H₂O / 0.5 h

With hydrogen; palladium on activated charcoal; In water; N,N-dimethyl-formamide;

DOI:10.1021/jm00403a016

Reference yield:

mitomycin C (170899-74-8) → 1-Hydroxy-2,7-diaminomitosen (1096-49-7,102679-60-7,102679-61-8,78655-54-6)

Guidance literature:

With phosphate buffer; In methanol; water; at 40 ℃; Rate constant; Mechanism; Thermodynamic data; degradation, influence of pH, anion nature, enthalpy of activation;

DOI:10.1002/jps.2600720518

upstream raw materials:

2,7-diamino-1-hydroxymitosene 1-uridilate

mitomycin C

mitomycin C