Chemical Property of Dihydrokainic acid
Chemical Property:
- Vapor Pressure:4.14E-08mmHg at 25°C
- Melting Point:285 °C (decomp)
- Boiling Point:416.6°Cat760mmHg
- PKA:2.11±0.60(Predicted)
- Flash Point:205.8°C
- PSA：86.63000
- Density:1.187g/cm3
- LogP:0.73470
- Storage Temp.:2-8°C
- Solubility.:H2O: >10 mg/mL
- XLogP3:-1.7
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:4
- Exact Mass:215.11575802
- Heavy Atom Count:15
- Complexity:264
- Purity/Quality:
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98%,99%, *data from raw suppliers
Dihydrokainic acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
20/21/22
- Safety Statements:
26-36
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC(C)C1CNC(C1CC(=O)O)C(=O)O
- Isomeric SMILES:CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
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Description
Dihydrokainic acid (DHK) is an inhibitor of excitatory amino acid transporter 2 (EAAT2; Ki = 23 μM for glutamate uptake by COS cells expressing EAAT2). It is selective for EEAT2 over EAAT1 and EAAT3 (Ki = >3 mM for both). DHK microinfusion (5 nmol) into the rat infralimbic cortex reduces the time spent immobile in the forced swim test, indicating antidepressant-like behavior, an effect that is blocked by the AMPA receptor antagonist NBQX and the serotonin (5-HT) receptor subtype 5-HT1A antagonist WAY-100635 . It also increases glutamate and serotonin levels and the expression of c-Fos in the dorsal raphe nucleus. In contrast, DHK microinjection (6.25 nmol) into the rat prefrontal cortex (PFC) increases the latency to drink sucrose in a sucrose intake test, indicating anhedonia-like behavior. It also impairs memory acquisition, consolidation, and retrieval in mice in the novel object recognition test.
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Uses
Dihydrokainic acid has been used as a glutamate transporter (GLT-1) inhibitor in the glutamate uptake assay of astrocytes and glial cells. It may be used as a GLT-1 inhibitor in Lateral habenula (LHb).
