Technology Process of Benz[a]anthracene-8-acetic acid
There total 6 articles about Benz[a]anthracene-8-acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium hydroxide;
In
methanol;
for 1h;
Heating;
DOI:10.1021/jo00158a012
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 83 percent / zinc dust, iodine / benzene; diethyl ether / 1.) 15 min, reflux, 2.) 2h, reflux
2: 1.) p-TsOH, 2.) 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) / 1.) benzene, reflux, 2h, 2.) reflux, 4h
3: 88 percent / aq. KOH / methanol / 1 h / Heating
With
potassium hydroxide; iodine; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc;
In
methanol; diethyl ether; benzene;
DOI:10.1021/jo00158a012
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 70 percent / polyphosphoric acid / 3 h / 80 °C
2: 83 percent / zinc dust, iodine / benzene; diethyl ether / 1.) 15 min, reflux, 2.) 2h, reflux
3: 1.) p-TsOH, 2.) 2,3-dichloro-5,6-dicyanobenzoquinone (DDQ) / 1.) benzene, reflux, 2h, 2.) reflux, 4h
4: 88 percent / aq. KOH / methanol / 1 h / Heating
With
potassium hydroxide; PPA; iodine; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc;
In
methanol; diethyl ether; benzene;
DOI:10.1021/jo00158a012
