aphidicolin-17-monoacetate

Base Information

Chemical Name:aphidicolin-17-monoacetate
CAS No.:51103-57-2
Molecular Formula:C₂₂H₃₆O₅
Molecular Weight:380.525
Hs Code.:

Synonyms:8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, a9-acetate, (3a,4a,4aa,6ab,8b,9b,11ab,11bb)- (9CI); Aphidicolin 17-acetate; Aphidicolin 17-monoacetate

Suppliers and Price of aphidicolin-17-monoacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Adipogen Life Sciences
Aphidicolin17-acetate ≥96%(HPLC,1H-NMR)
250 μg
$ 90.00

Total 5 raw suppliers

Chemical Property of aphidicolin-17-monoacetate

Chemical Property:

Vapor Pressure:1.14E-12mmHg at 25°C
Boiling Point:513°Cat760mmHg
Flash Point:171.8°C
PSA：86.99000
Density:1.21g/cm³
LogP:2.65660

Purity/Quality:

99% ^*data from raw suppliers

Aphidicolin17-acetate ≥96%(HPLC,1H-NMR) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of aphidicolin-17-monoacetate

There total 13 articles about aphidicolin-17-monoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 135404-93-2
3α,18-bis-tert-butyldimethylsilyloxyaphidicolin 17-acetate

: 51103-57-2
(+)-aphidicolin 17-acetate

Guidance literature:: With hydrogen fluoride; In dichloromethane; acetonitrile; a) -5 deg C, 5 min, b) room temp., 15 min;

Reference yield:

: 121741-51-3
methyl 3α,18-isopropylidenedioxyaphidicol-15-ene-16-carboxylate

: 51103-57-2
(+)-aphidicolin 17-acetate

Guidance literature:: Multi-step reaction with 11 steps

1: 90 percent / m-CPBA, disodium phosphate, bis(2-tert-butyl-3-hydroxy-4-methylphenyl)sulphide / CH₂Cl₂ / 8 h / Heating

2: 100 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

3: 100 percent / BIO-RAD AG₅₀W-X₂ 50-100 mesh H⁺ ion exchange resin / methanol / 2 h / Heating

4: 88 percent / HIO₄ / pyridine; H₂O / 0.33 h / Ambient temperature

5: 84 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 0.08 h / -5 °C

6: 99 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / Ambient temperature

7: 80 percent / Et₃N / palladium(II)acetate, triphenylphosphine / dimethylformamide

8: 87 percent / m-CPBA, disodium phosphate, bis(2-tert-butyl-3-hydroxy-4-methylphenyl)sulphide / CH₂Cl₂ / 8 h / Heating

9: 96 percent / LiAlH₄ / tetrahydrofuran / Heating

10: 98 percent / DMAP, pyridine / CH₂Cl₂ / 0.5 h

11: 86 percent / 48percent hydrofluoric acid / CH₂Cl₂; acetonitrile / a) -5 deg C, 5 min, b) room temp., 15 min

With pyridine; 2,6-dimethylpyridine; dmap; disodium hydrogenphosphate; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; bis(2-tert-butyl-3-hydroxy-4-methylphenyl)sulphide; BIO-RAD AG₅₀W-X₂ 50-100 mesh H⁺ ion exchange resin; hydrogen fluoride; periodic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 121741-52-4
methyl 15β,16β-epoxy-3α,18-isopropylidenedioxyaphidicolane-16α-carboxylate

: 51103-57-2
(+)-aphidicolin 17-acetate

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

2: 100 percent / BIO-RAD AG₅₀W-X₂ 50-100 mesh H⁺ ion exchange resin / methanol / 2 h / Heating

3: 88 percent / HIO₄ / pyridine; H₂O / 0.33 h / Ambient temperature

4: 84 percent / 2,6-dimethylpyridine / CH₂Cl₂ / 0.08 h / -5 °C

5: 99 percent / 2,6-di-tert-butyl-4-methylpyridine / CH₂Cl₂ / Ambient temperature

6: 80 percent / Et₃N / palladium(II)acetate, triphenylphosphine / dimethylformamide

7: 87 percent / m-CPBA, disodium phosphate, bis(2-tert-butyl-3-hydroxy-4-methylphenyl)sulphide / CH₂Cl₂ / 8 h / Heating

8: 96 percent / LiAlH₄ / tetrahydrofuran / Heating

9: 98 percent / DMAP, pyridine / CH₂Cl₂ / 0.5 h

10: 86 percent / 48percent hydrofluoric acid / CH₂Cl₂; acetonitrile / a) -5 deg C, 5 min, b) room temp., 15 min

With pyridine; 2,6-dimethylpyridine; dmap; disodium hydrogenphosphate; lithium aluminium tetrahydride; 2,6-di-tert-butyl-4-methylpyridine; bis(2-tert-butyl-3-hydroxy-4-methylphenyl)sulphide; BIO-RAD AG₅₀W-X₂ 50-100 mesh H⁺ ion exchange resin; hydrogen fluoride; periodic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;