4-phenyltetrahydro-2H-pyran-4-carbonitrile

Base Information

• Chemical Name: 4-phenyltetrahydro-2H-pyran-4-carbonitrile
• CAS No.: 1202-81-9
• Molecular Formula: C12H13 N O
• Molecular Weight: 187.241
• Hs Code.: 2932999099
• Mol file: 1202-81-9.mol

Synonyms:Pyran-4-carbonitrile,tetrahydro-4-phenyl- (7CI); 4-Cyano-4-phenyltetrahydropyran; NSC 10064

Chemical Property of 4-phenyltetrahydro-2H-pyran-4-carbonitrile

Chemical Property:

• Vapor Pressure: 9.09E-05mmHg at 25°C
• Melting Point: 49-50 °C
• Boiling Point: 339.6°C at 760 mmHg
• Flash Point: 143.3°C
• PSA: 33.02000
• Density: 1.09g/cm³
• LogP: 2.25838

Purity/Quality:

97% ^*data from raw suppliers

4-Phenyltetrahydro-2H-pyran-4-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 4-phenyltetrahydro-2H-pyran-4-carbonitrile

There total 3 articles about 4-phenyltetrahydro-2H-pyran-4-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

phenylacetonitrile (140-29-4) + 3-oxa-1,5-dichloropentane (111-44-4) → 4-phenyltetrahydro-2H-pyran-4-carbonitrile (1202-81-9)

Guidance literature:

With sodium hydride; sodium iodide; In dimethyl sulfoxide; mineral oil; at 20 ℃; for 12h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201600305

Reference yield: 93.0%

C-(4-phenyl-tetrahydro-pyran-4-yl)-methylamine (14006-32-7) → 4-phenyltetrahydro-2H-pyran-4-carbonitrile (1202-81-9)

Guidance literature:

With ammonium hydroxide; oxygen; In tert-Amyl alcohol; at 110 ℃; for 15h; under 2250.23 Torr; Autoclave; Green chemistry;

DOI:10.1002/cssc.201402613

Reference yield:

→ 4-phenyltetrahydro-2H-pyran-4-carbonitrile (1202-81-9)

Guidance literature:

aus Phenylacetonitril, 2,2'-Dichlordiaethylaether, wss.NaOH in Ggw.von Triaethylbenzylammoniumchlorid, 35-40grad;

upstream raw materials:

phenylacetonitrile

3-oxa-1,5-dichloropentane

C-(4-phenyl-tetrahydro-pyran-4-yl)-methylamine

Downstream raw materials:

1-(4-phenyl-tetrahydropyran-4-yl)-ethanone

4-phenyltetrahydro-2H-pyran-4-carboxylic acid

5-(4-phenyl-tetrahydro-pyran-4-yl)-1⁽²⁾H-tetrazole

4-bromo-2-(2-bromo-ethyl)-2-phenyl-butyric acid