2-(4-CHLOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)-2-PROPANOL

Base Information

• Chemical Name: 2-(4-CHLOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)-2-PROPANOL
• CAS No.: 81886-49-9
• Molecular Formula: C₁₃H₁₃ClN₆O
• Molecular Weight: 304.739
• Mol file: 81886-49-9.mol

Synonyms:2-(4-CHLOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)-2-PROPANOL

Chemical Property of 2-(4-CHLOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)-2-PROPANOL

Chemical Property:

• Vapor Pressure: 3.08E-15mmHg at 25°C
• Boiling Point: 599.8°C at 760 mmHg
• Flash Point: 316.6°C
• PSA: 81.65000
• Density: 1.45g/cm³
• LogP: 1.11100

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

2-(4-CHLOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)-2-PROPANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-CHLOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)-2-PROPANOL

There total 2 articles about 2-(4-CHLOROPHENYL)-1,3-BIS(1H-1,2,4-TRIAZOL-1-YL)-2-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

1,2,4-Triazole (288-88-0) + trimethylsulfoxonium iodide (1774-47-6) + 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone (58905-19-4) → 1,3-bis(1H-1,2,4-triazol-1-yl)-2-(4-chlorophenyl)-2-propanol (81886-49-9)

Guidance literature:

With potassium hydroxide; In tert-butyl alcohol; for 48h; Heating;

DOI:10.1002/jhet.5570300538

Reference yield:

1-(4-chlorophenacyl)-4-amino-1H-1,2,4-triazolium bromide (126961-65-7) → 1,3-bis(1H-1,2,4-triazol-1-yl)-2-(4-chlorophenyl)-2-propanol (81886-49-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / aq. HCl, NaNO₂ / 0.25 h / Ambient temperature

2: 50 percent / KOH / 2-methyl-propan-2-ol / 48 h / Heating

With hydrogenchloride; potassium hydroxide; sodium nitrite; In tert-butyl alcohol;

DOI:10.1002/jhet.5570300538

upstream raw materials:

1,2,4-Triazole

trimethylsulfoxonium iodide

1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone

1-(4-chlorophenacyl)-4-amino-1H-1,2,4-triazolium bromide