Rifamycin P

Base Information

• Chemical Name: Rifamycin P
• CAS No.: 59232-87-0
• Molecular Formula: C38H46 N2 O11 S
• Molecular Weight: 738.856
• Mol file: 59232-87-0.mol

Synonyms:rifamycin P

Chemical Property of Rifamycin P

Chemical Property:

• Boiling Point: 934.3oC at 760 mmHg
• Flash Point: 518.8oC
• PSA: 225.70000
• Density: 1.38g/cm3
• LogP: 5.74330
• XLogP3: 6.3
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 3
• Exact Mass: 738.28223146
• Heavy Atom Count: 52
• Complexity: 1420

Purity/Quality:

99% ^*data from raw suppliers

RIFAMYCIN P 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1C=CC=C(C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(OC=CC(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2SC=N5)O)C
• Isomeric SMILES: CC1/C=C/C=C(/C(=O)NC2=C(C3=C(C4=C(C(=C3O)C)OC(C4=O)(O/C=C\C(C(C(C(C(C(C1O)C)O)C)OC(=O)C)C)OC)C)C5=C2SC=N5)O)\C

Technology Process of Rifamycin P

There total 6 articles about Rifamycin P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

rifamycin S (13553-79-2) → rifamycin P (59232-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.4 g / methanol / 72 h / Ambient temperature; pH= 4.6

2: 1.7 g / 10percent Na₂CO₃ aq / acetone / 4 h / Ambient temperature

With sodium carbonate; In methanol; acetone;

DOI:10.1016/0040-4020(80)85056-3

Reference yield:

2'-carbomethoxythiazole (5,4-c)-4-deoxy-rifamycin SV (65990-91-2) → rifamycin P (59232-87-0)

Guidance literature:

With sodium carbonate; In acetone; for 4h; Ambient temperature;

DOI:10.1016/0040-4020(80)85056-3

Reference yield:

3-<2-amino-2(methoxycarbonyl)ethyl-thio>rifamycin SV (65981-44-4) → rifamycin P (59232-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 g / rifamycin S / methanol / 16 h / Ambient temperature; pH= 4.6, further oxidizing agents

2: 1.7 g / 10percent Na₂CO₃ aq / acetone / 4 h / Ambient temperature

With sodium carbonate; rifamycin S; In methanol; acetone;

DOI:10.1016/0040-4020(80)85056-3

upstream raw materials:

2'-carbomethoxythiazole (5,4-c)-4-deoxy-rifamycin SV

rifamycin S

3-<2-amino-2(methoxycarbonyl)ethyl-thio>rifamycin SV

Downstream raw materials:

C₄₈H₅₈N₄O₁₁S

2'-(N,N-diethylamino)rifamycin P

C₅₀H₆₀N₄O₁₃S

C₄₉H₆₀N₄O₁₂S