Thalidezine

Base Information

• Chemical Name: Thalidezine
• CAS No.: 18251-36-0
• Molecular Formula: C₃₈H₄₂N₂O₇
• Molecular Weight: 638.761
• Mol file: 18251-36-0.mol

Synonyms:Berbaman-5-ol,6,6',7,12-tetramethoxy-2,2'-dimethyl-, (1b)-; Thalidezine (8CI);16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline,berbaman-5-ol deriv.; NSC 269188; Thalidesine

Chemical Property of Thalidezine

Chemical Property:

• Melting Point: 158-159℃
• Boiling Point: 735°Cat760mmHg
• PKA: 9.71±0.20(Predicted)
• Flash Point: 398.3°C
• PSA: 82.09000
• Density: 1.206g/cm³
• LogP: 6.74380

Purity/Quality:

95%-98% ^*data from raw suppliers

Thalidezine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: A further alkaloid of the bisbenzylisoquinoline type found in Thalictrum fendleri Engelm, this base yields colourless crystals from Me2CO and has [α]25D + 236° (CHCl3). The ultraviolet spectrum has one absorption maximum at 283 mJ.1. The D-methyl ether is identical with Hernandezine (q.v.). The D-ethy1 ether forms colourless crystals with m.p. 117-120° C.
• Uses: Thalidezine is an isoquinoline alkaloid used in the treatments of cancers and neurodegenerative diseases.

Technology Process of Thalidezine

There total 2 articles about Thalidezine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Tetrandrin (518-34-3,5990-67-0) → thalidezine (18251-36-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂, AcOH, CF₃CO₂H / H₂O / 0.08 h / Heating

2: (i) nBuLi, (ii) PhNO₂

With bromine; acetic acid; trifluoroacetic acid; In water;

DOI:10.1021/jo00433a019

Reference yield:

tetrandrine bromide (62067-29-2) → thalidezine (18251-36-0)

Guidance literature:

Multistep reaction; (i) nBuLi, (ii) PhNO₂;

DOI:10.1021/jo00433a019

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + thalidezine (18251-36-0) → Hernandezine (6681-13-6)

Guidance literature:

DOI:10.1021/jo00433a019

upstream raw materials:

tetrandrine bromide

Tetrandrin

Downstream raw materials:

Hernandezine

Refernces