ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

Base Information

Chemical Name:ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
CAS No.:4450-98-0
Molecular Formula:C14H15 N O4
Molecular Weight:261.277
Hs Code.:2933990090
Mol file:4450-98-0.mol

Synonyms:3-Pyrroline-3-carboxylicacid, 1-benzyl-4-hydroxy-5-oxo-, ethyl ester (7CI,8CI); EBPC; NSC 229530

Suppliers and Price of ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
EBPC
1mg
$ 45.00

Sigma-Aldrich
EBPC ≥98% (HPLC)
25mg
$ 408.00

Sigma-Aldrich
EBPC ≥98% (HPLC)
5mg
$ 105.00

Medical Isotopes, Inc.
EBPC
100 mg
$ 2120.00

Matrix Scientific
1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95+%
10mg
$ 152.00

Matrix Scientific
1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester 95+%
50mg
$ 613.00

CSNpharm
EBPC
100mg
$ 751.00

Cayman Chemical
EBPC ≥98%
1mg
$ 25.00

Cayman Chemical
EBPC ≥98%
5mg
$ 75.00

Cayman Chemical
EBPC ≥98%
10mg
$ 113.00

Total 10 raw suppliers

Chemical Property of ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

Chemical Property:

Vapor Pressure:2.09E-07mmHg at 25°C
Boiling Point:408.5°C at 760 mmHg
Flash Point:200.9°C
PSA：66.84000
Density:1.327g/cm³
LogP:1.34190
Storage Temp.:room temp
Solubility.:DMSO: ≥10mg/mL

Purity/Quality:

98%min ^*data from raw suppliers

EBPC ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-41
Safety Statements: 26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Description The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF2α synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC50 value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F2α (PGF2α) and PGE2 production in human endometrial cells with an EC50 value of 10 μM.
Uses A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.

Technology Process of ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

There total 2 articles about ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: