Atiprimod

Base Information

Chemical Name:Atiprimod
CAS No.:123018-47-3
Molecular Formula:C₂₂H₄₄N₂
Molecular Weight:336.605
Hs Code.:
UNII:MG7D3QD743
DSSTox Substance ID:DTXSID10153834
Nikkaji Number:J351.780B
Wikipedia:Atiprimod
Wikidata:Q4815831
NCI Thesaurus Code:C52184
Metabolomics Workbench ID:149500
ChEMBL ID:CHEMBL103735

Synonyms:antiprimod;atiprimod;azaspirane;N,N-diethyl-8,8-dipropyl-2-azaspiro(4.5)decane-2-propanamine dihydrochloride;SK and F 106615;SK and F 106615, dihydrochloride;SK and F-106615;SKF 106615;SKF-106615

Suppliers and Price of Atiprimod

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Atiprimod

Chemical Property:

Boiling Point:390°Cat760mmHg
Flash Point:166.5°C
Density:0.91g/cm³
XLogP3:6.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:10
Exact Mass:336.350449412
Heavy Atom Count:24
Complexity:332

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCC1(CCC2(CC1)CCN(C2)CCCN(CC)CC)CCC
Recent ClinicalTrials:Study of Atiprimod Treatment for Patients With Advanced Cancer

Technology Process of Atiprimod

There total 16 articles about Atiprimod which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 253335-95-4
[3-(14,14-dipropyl-1,4-dithia-9-aza-dispiro[4.1.4.3]tetradec-9-yl)-propyl]-diethyl-amine

: 123018-47-3
atiprimod

Guidance literature:: With hydrogen; nickel; In ethanol; Heating;
DOI:10.1016/j.tetlet.2006.07.100

Reference yield:

: 60729-41-1
4,4-dipropylcyclohex-2-en-1-one

: 123018-47-3
atiprimod

Guidance literature:: Multi-step reaction with 7 steps

1: 98 percent / H₂ / 10percent Pd/C / ethyl acetate / 5 h / 2585.7 Torr / Ambient temperature

2: 89 percent / ammonium acetate, acetic acid / toluene / Heating

3: ethanol; H₂O / 5 h / Heating

4: acetic acid, hydrochloric acid, H₂O / 84 h / Heating

5: 89 percent / acetic anhydride / 4 h / Heating

6: Heating

7: LiAlH₄ / diethyl ether / 3 h

With ammonium acetate; hydrogenchloride; lithium aluminium tetrahydride; water; hydrogen; acetic anhydride; acetic acid; palladium on activated charcoal; In diethyl ether; ethanol; water; ethyl acetate; toluene;
DOI:10.1021/jm00173a010

Reference yield:

: 253333-59-4
2-(3-diethylamino-propyl)-7,9-dimethoxy-2-aza-spiro[4.5]deca-6,9-dien-1-one

: 123018-47-3
atiprimod

Guidance literature:: Multi-step reaction with 8 steps

1.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran

2.1: t-BuLi; HMPA / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran

3.1: 93 percent / LiAlH₄ / tetrahydrofuran / Heating

4.1: 95 percent / aq. HCl

5.1: 42 percent / BF₃*OEt₂ / 90 °C

6.1: 39 percent / hydrogen / Raney nickel / ethanol / Heating

7.1: 64 percent / BF₃*OEt₂ / 90 °C

8.1: 43 percent / hydrogen / Raney nickel / ethanol / Heating

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; hydrogen; tert.-butyl lithium; nickel; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tetlet.2006.07.100