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Technology Process of methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

Base Information Edit
  • Chemical Name:methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
  • CAS No.:98791-67-4
  • Molecular Formula:C16H15F3N2O4
  • Molecular Weight:356.301
  • Hs Code.:
  • European Community (EC) Number:635-578-9
  • DSSTox Substance ID:DTXSID00913080
  • Nikkaji Number:J330.329B
  • Pharos Ligand ID:QXRDVUV3FYRB
  • ChEMBL ID:CHEMBL105672
  • Mol file:98791-67-4.mol
methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate

Synonyms:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester;Bay K 8644;Bay K8644;Bay R 5417;Bay R5417;Bay-K-8644;Bay-K-8644, (+)-Isomer;Bay-K-8644, (+-)-Isomer;Bay-K-8644, (-)-Isomer;Bay-K8644;Bay-R-5417;BayK8644;BayR5417;BK 8644;BK-8644;BK8644;R5417, Bay

Suppliers and Price of methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • (R)-(+)-BayK8644
  • 2.5mg
  • $ 225.00
  • Tocris
  • (R)-(+)-BayK8644 ≥97%(HPLC)
  • 50
  • $ 1184.00
  • Crysdot
  • Bay-K-8644(R)-(+)- 98+%
  • 10mg
  • $ 126.00
  • Crysdot
  • Bay-K-8644(R)-(+)- 98+%
  • 5mg
  • $ 95.00
  • Crysdot
  • Bay-K-8644(R)-(+)- 98+%
  • 50mg
  • $ 518.00
  • ChemScene
  • (R)-(+)-Bay-K-8644 99.69%
  • 100mg
  • $ 1350.00
  • ChemScene
  • (R)-(+)-Bay-K-8644 99.69%
  • 50mg
  • $ 800.00
  • ChemScene
  • (R)-(+)-Bay-K-8644 99.69%
  • 25mg
  • $ 450.00
  • ChemScene
  • (R)-(+)-Bay-K-8644 99.69%
  • 5mg
  • $ 150.00
  • ChemScene
  • (R)-(+)-Bay-K-8644 99.69%
  • 10mg
  • $ 200.00
Total 11 raw suppliers
Chemical Property of methyl (4R)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate Edit
Chemical Property:
  • Vapor Pressure:1.43E-07mmHg at 25°C 
  • Boiling Point:429.2°C at 760 mmHg 
  • Flash Point:213.4°C 
  • PSA：84.15000 
  • Density:1.37g/cm3 
  • LogP:4.19940 
  • Storage Temp.:2-8°C 
  • Solubility.:H2O: slightly soluble 
  • XLogP3:3.4
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:8
  • Rotatable Bond Count:3
  • Exact Mass:356.09839145
  • Heavy Atom Count:25
  • Complexity:634
Purity/Quality:

97% *data from raw suppliers

(R)-(+)-BayK8644 *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:Xi 
  • Statements: 36/38 
  • Safety Statements: 26-36 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
  • Isomeric SMILES:CC1=C([C@H](C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC
  • Description BAY-K-8644, originally described as a modulator of potential operated calcium channels, exists as two enantiomers that have opposite actions. (R)-(+)-BAY-K-8644 is an L-type channel blocker that has negative inotropic and vasodilatory effects at 1 μM. Intracerebroventricular administration of this enantiomer has no effect on motor function in mice, whereas (S)-(?)-BAY-K-8644 impairs rotarod and motor activity, an effect that is blocked by (R)-(+)-BAY-K-8644.
  • Uses (R)-(+)-Bay K 8644 is a Ca2+ channel inhibitor, whose enantiomer is a Ca2+ channel activator.

Total 8 Pictures about this product

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