8,9-Dihydro-10-methyl-7-((5-methyl-1H-imidazol-4-yl)methyl)pyrido(1,2-a)indol-6(7H)-one

Base Information

• Chemical Name: 8,9-Dihydro-10-methyl-7-((5-methyl-1H-imidazol-4-yl)methyl)pyrido(1,2-a)indol-6(7H)-one
• CAS No.: 129299-72-5
• Molecular Formula: C₁₈H₁₉N₃O
• Molecular Weight: 293.368
• DSSTox Substance ID: DTXSID50861300
• Nikkaji Number: J550.167I

Synonyms:8,9-dihydro-10-dihydro-10-methyl-7-((5-methyl-4-imidazolyl)methyl)pyrido-(1-2a)-indol-6(7H)-one;FK 1052;FK 1052, (+)-isomer;FK 1052, (-)-isomer;FK 1052, hydrochloride;FK 1052, hydrochloride, (+)-isomer;FK-1052;FK1052

Chemical Property of 8,9-Dihydro-10-methyl-7-((5-methyl-1H-imidazol-4-yl)methyl)pyrido(1,2-a)indol-6(7H)-one

Chemical Property:

• Vapor Pressure: 1.28E-12mmHg at 25°C
• Boiling Point: 561.1°Cat760mmHg
• Flash Point: 293.1°C
• Density: 1.3g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 293.152812238
• Heavy Atom Count: 22
• Complexity: 440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2CCC(C(=O)N2C3=CC=CC=C13)CC4=C(NC=N4)C

Technology Process of 8,9-Dihydro-10-methyl-7-((5-methyl-1H-imidazol-4-yl)methyl)pyrido(1,2-a)indol-6(7H)-one

There total 18 articles about 8,9-Dihydro-10-methyl-7-((5-methyl-1H-imidazol-4-yl)methyl)pyrido(1,2-a)indol-6(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(+/-)-8,9-dihydro-10-(dimethylaminomethyl)-7-<(5-methyl-1H-imidazol-4-yl)methyl>pyrido<1,2-a>indol-6(7H)-one (138476-77-4) → (+/-)-8,9-dihydro-10-methyl-7-<(5-methyl-1H-imidazol-4-yl)methyl>pyrido<1,2-a>indol-6(7H)-one (129299-72-5)

Guidance literature:

With ammonium formate; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; at 80 ℃; for 2.33333h;

DOI:10.1248/cpb.43.1346

Reference yield:

8,9-dihydro-7-<(hydroxy)<5-methyl-1-(triphenylmethyl)-1H-imidazol-4-yl>methyl>-10-methylpyrido<1,2-a>indol-6(7H)-one (138476-55-8) → (+/-)-8,9-dihydro-10-methyl-7-<(5-methyl-1H-imidazol-4-yl)methyl>pyrido<1,2-a>indol-6(7H)-one (129299-72-5)

Guidance literature:

With sodium hydroxide; ammonium formate; palladium; In acetic acid;

Reference yield:

7-[(1-benzyl-5-methyl-1H-imidazol-4-yl)methyl]-10-[(dimethylamino)methyl]-8,9-dihydropyrido[1,2-a]indol-6(7H)-one → (+/-)-8,9-dihydro-10-methyl-7-<(5-methyl-1H-imidazol-4-yl)methyl>pyrido<1,2-a>indol-6(7H)-one (129299-72-5)

Guidance literature:

With ammonium formate; palladium; In tetrahydrofuran; ethanol; water;

upstream raw materials:

8,9-dihydro-10-methyl-7-<<5-methyl-1-(triphenylmethyl)-1H-imidazol-4-yl>methylene>pyrid<1,2-a>indol-6(7)-one

(+/-)-8,9-dihydro-10-(dimethylaminomethyl)-7-<(5-methyl-1H-imidazol-4-yl)methyl>pyrido<1,2-a>indol-6(7H)-one

6,7,8,9-tetrahydropyrido[1,2-a]indol-6-one

<2-(2,6-dioxopiperidin-1-yl)phenylmethyl>triphenylphosphonium bromide

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