1-(1-Naphthylmethyl)piperidine

Base Information

• Chemical Name: 1-(1-Naphthylmethyl)piperidine
• CAS No.: 6947-74-6
• Molecular Formula: C16H19N
• Molecular Weight: 225.3288
• NSC Number: 56140
• DSSTox Substance ID: DTXSID00219690
• Nikkaji Number: J2.943.891I
• Wikidata: Q83096673
• Mol file: 6947-74-6.mol

Synonyms:1-(1-Naphthylmethyl)piperidine;Piperidine, 1-(1-naphthylmethyl)-;6947-74-6;1-(naphthalen-1-ylmethyl)piperidine;NSC 56140;BRN 0166948;NSC56140;piperidinomethylnaphthalene;5-20-02-00087 (Beilstein Handbook Reference);SCHEMBL807336;DTXSID00219690;NSC-56140;STK024622;AKOS003974900

Chemical Property of 1-(1-Naphthylmethyl)piperidine

Chemical Property:

• Vapor Pressure: 5.25E-05mmHg at 25°C
• Boiling Point: 347.8°C at 760 mmHg
• Flash Point: 148.5°C
• Density: 1.073g/cm³
• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 225.151749610
• Heavy Atom Count: 17
• Complexity: 232

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)CC2=CC=CC3=CC=CC=C32

Technology Process of 1-(1-Naphthylmethyl)piperidine

There total 5 articles about 1-(1-Naphthylmethyl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(naphthalen-1-yl)(piperidin-1-yl)methanone (5454-14-8) → 1-((piperidine-1-yl)methyl)naphthalene (6947-74-6)

Guidance literature:

With diethoxymethylane; zinc diacetate; In tetrahydrofuran; at 65 ℃; chemoselective reaction; Inert atmosphere;

DOI:10.1002/chem.201101143

Reference yield: 84.0%

1-naphthyl mesylate (38262-42-9) + N-(trifluoroboratomethyl)piperidine internal salt (1268340-93-7) → 1-((piperidine-1-yl)methyl)naphthalene (6947-74-6)

Guidance literature:

With potassium phosphate; palladium diacetate; XPhos; In water; tert-butyl alcohol; at 110 ℃; for 1h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol200128y

Reference yield: 81.0%

N-(trifluoroboratomethyl)piperidine internal salt (1268340-93-7) + 1-naphthyl tosylate (68211-49-4) → 1-((piperidine-1-yl)methyl)naphthalene (6947-74-6)

Guidance literature:

With potassium phosphate; palladium diacetate; XPhos; In water; tert-butyl alcohol; at 110 ℃; for 4h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol200128y

upstream raw materials:

piperidine

1-Chloromethylnaphthalene

1-naphthyl mesylate

N-(trifluoroboratomethyl)piperidine internal salt