3,6-Dihydro-alpha-(4-((4-chlorophenyl)methyl)phenyl)-4-phenyl-1(2H)-pyridinepropanol

Base Information

Chemical Name:3,6-Dihydro-alpha-(4-((4-chlorophenyl)methyl)phenyl)-4-phenyl-1(2H)-pyridinepropanol
CAS No.:143462-72-0
Molecular Formula:C₂₇H₂₈ClNO
Molecular Weight:417.978
Hs Code.:
DSSTox Substance ID:DTXSID50931890
Nikkaji Number:J590.579F

Synonyms:3,6-Dihydro-alpha-(4-((4-chlorophenyl)methyl)phenyl)-4-phenyl-1(2H)-pyridinepropanol;1(2H)-Pyridinepropanol, 3,6-dihydro-alpha-(4-((4-chlorophenyl)methyl)phenyl)-4-phenyl-;143462-72-0;C27H28ClNO;SCHEMBL8970731;C27-H28-Cl-N-O;DTXSID50931890;LS-131920;1-{4-[(4-Chlorophenyl)methyl]phenyl}-3-(4-phenyl-3,6-dihydropyridin-1(2H)-yl)propan-1-ol;alpha-[4-(4-Chlorobenzyl)phenyl]-4-phenyl-1,2,3,6-tetrahydropyridine-1-(1-propanol)

Suppliers and Price of 3,6-Dihydro-alpha-(4-((4-chlorophenyl)methyl)phenyl)-4-phenyl-1(2H)-pyridinepropanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 3,6-Dihydro-alpha-(4-((4-chlorophenyl)methyl)phenyl)-4-phenyl-1(2H)-pyridinepropanol

Chemical Property:

Vapor Pressure:1.18E-14mmHg at 25°C
Boiling Point:587.7°Cat760mmHg
Flash Point:309.2°C
Density:1.169g/cm³
XLogP3:5.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:7
Exact Mass:417.1859422
Heavy Atom Count:30
Complexity:527

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CC=C1C2=CC=CC=C2)CCC(C3=CC=C(C=C3)CC4=CC=C(C=C4)Cl)O

Technology Process of 3,6-Dihydro-alpha-(4-((4-chlorophenyl)methyl)phenyl)-4-phenyl-1(2H)-pyridinepropanol

There total 4 articles about 3,6-Dihydro-alpha-(4-((4-chlorophenyl)methyl)phenyl)-4-phenyl-1(2H)-pyridinepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1-[4-(4-Chloro-benzyl)-phenyl]-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-propan-1-one; hydrochloride

: 143462-72-0,180959-21-1,180959-23-3
(+/-)-1-<4-(4-chlorobenzyl)-phenyl>-3-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)-1-propanol

Guidance literature:: With sodium hydroxide; sodium tetrahydroborate; In methanol; Ambient temperature;
DOI:10.1016/0223-5234(94)90059-0

Reference yield:

: 10338-69-9
1,2,3,6-tetrahydro-4-phenylpyridine

: 143462-72-0,180959-21-1,180959-23-3
(+/-)-1-<4-(4-chlorobenzyl)-phenyl>-3-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)-1-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / HCl / ethanol / 24 h / Heating

2: 93 percent / NaOH, NaBH₄ / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; In methanol; ethanol;
DOI:10.1016/0223-5234(94)90059-0

Reference yield:

: 831-81-2
4-chlorophenyl(phenyl)methane

: 143462-72-0,180959-21-1,180959-23-3
(+/-)-1-<4-(4-chlorobenzyl)-phenyl>-3-(4-phenyl-1,2,3,6-tetrahydropyridin-1-yl)-1-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: AlCl₃ / nitrobenzene / 6 h / Ambient temperature

2: 60 percent / HCl / ethanol / 24 h / Heating

3: 93 percent / NaOH, NaBH₄ / methanol / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; aluminium trichloride; In methanol; ethanol; nitrobenzene;
DOI:10.1016/0223-5234(94)90059-0