3-amino-2,2,4,4-tetramethylcyclobutanol

Base Information

• Chemical Name: 3-amino-2,2,4,4-tetramethylcyclobutanol
• CAS No.: 14241-17-9
• Molecular Formula: C₈H₁₇NO
• Molecular Weight: 143.229

Synonyms:RP 1541

Chemical Property of 3-amino-2,2,4,4-tetramethylcyclobutanol

Chemical Property:

• Vapor Pressure: 0.17mmHg at 25°C
• Boiling Point: 187.9°Cat760mmHg
• Flash Point: 67.4°C
• Density: 0.94g/cm³

Purity/Quality:

99.3% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-amino-2,2,4,4-tetramethylcyclobutanol

There total 2 articles about 3-amino-2,2,4,4-tetramethylcyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ cis-3-Amino-2,2,4,4-tetramethyl-cyclobutanol (14241-17-9,802564-28-9)

Guidance literature:

3-Hydroxy-2,2,4,4-tetramethyl-cyclobutanonoxim XV, A., Ni-Schwamm, Hydrierung;

Reference yield:

→ 3-amino-2,2,4,4-tetramethylcyclobutanol (14241-17-9,802564-28-9)

Guidance literature:

Monoxim I, H2/Raney-Ni;

Reference yield:

3-amino-2,2,4,4-tetramethylcyclobutanol (14241-17-9,802564-28-9) → N-[trans-3-(3,4-dicyanophenoxy)-2,2,4,4-tetramethylcyclobutyl]acetamide

Guidance literature:

Multi-step reaction with 5 steps

1.1: phosphoric acid / ethanol / 2 h / 60 °C

2.1: potassium carbonate / 1,4-dioxane; water / 0 - 20 °C

3.1: sodium hydride / tetrahydrofuran / 10 - 20 °C

3.2: 10 °C / Reflux; Inert atmosphere

4.1: hydrogenchloride / 1,4-dioxane / 5 - 20 °C

5.1: triethylamine / dichloromethane / 0.5 h / 20 °C

With hydrogenchloride; phosphoric acid; sodium hydride; potassium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1021/jm201059s

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