Cefpirome

Base Information

Chemical Name:Cefpirome
CAS No.:84957-29-9
Molecular Formula:C₂₂H₂₂N₆O₅S₂
Molecular Weight:514.586
Hs Code.:3003201900
European Community (EC) Number:685-392-7
UNII:S72Q2F09HY
DSSTox Substance ID:DTXSID2048244
Wikipedia:Cefpirome
NCI Thesaurus Code:C79563
Metabolomics Workbench ID:49580
ChEMBL ID:CHEMBL65794
Mol file:84957-29-9.mol

Synonyms:3-((2,3-cyclopenteno-1-pyridinium)methyl)-7-(2-syn-methoximino-2-(2-aminothiazole-4-yl)acetamido)ceph-3-em-4-carboxylate;cefpirome;cefpirome sulfate;Cefrom;HR 810;HR-810;Metran

Suppliers and Price of Cefpirome

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Cefpirome 95+%
1g
$ 1424.00

American Custom Chemicals Corporation
CEFPIROME 95.00%
1G
$ 2804.55

Total 68 raw suppliers

Chemical Property of Cefpirome

Chemical Property:

Appearance/Colour:powder
PSA：207.46000
LogP:-0.13390
Storage Temp.:2-8°C(protect from light)
XLogP3:0.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:10
Rotatable Bond Count:6
Exact Mass:514.10931017
Heavy Atom Count:35
Complexity:955

Purity/Quality:

99% ^*data from raw suppliers

Cefpirome 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi
Statements: 36/37/38-42/43
Safety Statements: 22-26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CON=C(C1=CSC(=N1)N)C(=O)NC2C3N(C2=O)C(=C(CS3)C[N+]4=CC=CC5=C4CCC5)C(=O)[O-]
Isomeric SMILES:CO/N=C(/C1=CSC(=N1)N)\C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C[N+]4=CC=CC5=C4CCC5)C(=O)[O-]
Recent EU Clinical Trials:Cerebral microdialysis in neurointensive care patients to determine brain penetration of antibiotics. An open label explorative study.
Description This drug is resistant with respect to a broad spectrum of beta-lactamases. Its spectrum of activity is analogous to that of the third-generation cephalosporin cefotaxime (32.1.2.56), although it is more active with respect to some staphylococci, enterococci, and also a few enterobacteria. Synonyms of this drug are cefrom, cedixen, and others.
Uses Cephalosporin antibiotic Claforan
Clinical Use Cefpirome (Cefrom) is a newer parenteral, -lactamase–resistant cephalosporin with a quaternary ammonium groupat the 3-position of the cephem nucleus. Because its potencyagainst Gram-positive and Gram-negative bacteria rivals thatof the first-generation and third-generation cephalosporins,respectively, cefpirome is being touted as the first fourthgenerationcephalosporin. Its broad spectrum includesmethicillin-sensitive staphylococci, penicillin-resistantpneumococci, and β-lactamase–producing strains of E. coli,Enterobacter, Citrobacter, and Serratia spp. Its efficacyagainst P. aeruginosa is comparable with that of ceftazidime.Cefpirome is excreted largely unchanged in the urine with ahalf-life of 2 hours.

Technology Process of Cefpirome

There total 13 articles about Cefpirome which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63527-52-6,152186-43-1
cefotaxime

: 84957-29-9,97164-55-1,130431-30-0,92682-05-8
cefpirome

Guidance literature:: Multi-step reaction with 2 steps

1: CH₂Cl₂

2: CH₂Cl₂ / Heating

In dichloromethane;

Reference yield:

: 63527-52-6,152186-43-1
cefotaxime

: 533-37-9
2,3-cyclopentenopyridine

: 84957-29-9,97164-55-1,130431-30-0,92682-05-8
cefpirome

Guidance literature:: With potassium iodide; In water; at 70 ℃;

Reference yield:

: 104498-86-4
C₁₉H₂₅N₅O₇S₂Si

: 84957-29-9,97164-55-1,130431-30-0,92682-05-8
cefpirome

Guidance literature:: Multi-step reaction with 2 steps

1: trimethylsilyl iodide / 0.5 h / Ambient temperature

2: 2.) CH₃OH / 1.) acetonitrile, RT, 3 h, 2.) acetone

With methanol; trimethylsilyl iodide;
DOI:10.1021/jm00170a011