9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide

Base Information

• Chemical Name: 9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide
• CAS No.: 91549-81-4
• Molecular Formula: C₂₂H₂₈N₄O
• Molecular Weight: 364.491
• Mol file: 91549-81-4.mol

Synonyms:9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide

Chemical Property of 9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide

Chemical Property:

• Vapor Pressure: 1.17E-15mmHg at 25°C
• Boiling Point: 627.5°Cat760mmHg
• Flash Point: 333.3°C
• PSA: 74.74000
• Density: 1.152g/cm³
• LogP: 4.97800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide

There total 5 articles about 9-Amino-N-(6-(dimethylamino)hexyl)-4-acridinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-Phenoxy-acridine-4-carboxylic acid (6-dimethylamino-hexyl)-amide → 9-Amino-acridine-4-carboxylic acid (6-dimethylamino-hexyl)-amide (91549-81-4)

Guidance literature:

With ammonia; In various solvent(s); at 115 ℃;

DOI:10.1021/jm00377a017

Reference yield:

9-Oxoacridan-4-carboxylic acid (24782-64-7) → 9-Amino-acridine-4-carboxylic acid (6-dimethylamino-hexyl)-amide (91549-81-4)

Guidance literature:

Multi-step reaction with 4 steps

1: SOCl₂, DMF / Heating

2: CH₂Cl₂ / 30 °C

3: 50 °C

4: NH₃ gas / various solvent(s) / 115 °C

With thionyl chloride; ammonia; N,N-dimethyl-formamide; In dichloromethane;

DOI:10.1021/jm00377a017

Reference yield:

9-chloro-4-acridinecarbonyl chloride (89459-22-3) → 9-Amino-acridine-4-carboxylic acid (6-dimethylamino-hexyl)-amide (91549-81-4)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂ / 30 °C

2: 50 °C

3: NH₃ gas / various solvent(s) / 115 °C

With ammonia; In dichloromethane;

DOI:10.1021/jm00377a017

upstream raw materials:

9-Oxoacridan-4-carboxylic acid

9-chloro-4-acridinecarbonyl chloride

Vanadox

Refernces