[(2S,5R)-5-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)tetrahydrofuran-2-yl]methanol

Base Information

• Chemical Name: [(2S,5R)-5-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)tetrahydrofuran-2-yl]methanol
• CAS No.: 119898-95-2
• Molecular Formula: C₁₀H₁₃N₅O₂
• Molecular Weight: 235.246
• Mol file: 119898-95-2.mol

Synonyms:2-Furanmethanol,5-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)tetrahydro-, (2S-cis)-;1H-Pyrazolo[3,4-d]pyrimidine, 2-furanmethanol deriv.

Chemical Property of [(2S,5R)-5-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)tetrahydrofuran-2-yl]methanol

Chemical Property:

• Vapor Pressure: 2.25E-11mmHg at 25°C
• Boiling Point: 513.6°Cat760mmHg
• Flash Point: 264.4°C
• Density: 1.76g/cm³

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [(2S,5R)-5-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)tetrahydrofuran-2-yl]methanol

There total 7 articles about [(2S,5R)-5-(4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)tetrahydrofuran-2-yl]methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-amino-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo<3,4-d>pyrimidine (119898-94-1) → 4-amino-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-1H-pyrazolo<3,4-d>pyrimidine (119898-95-2)

Guidance literature:

With acetic acid; for 0.333333h; Ambient temperature;

DOI:10.1248/cpb.36.4153

Reference yield: 78.0%

1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-4-methoxy-1H-pyrazolo<3,4-d>pyrimidine → 4-amino-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-1H-pyrazolo<3,4-d>pyrimidine (119898-95-2)

Guidance literature:

With ammonium hydroxide; for 72h; Ambient temperature;

DOI:10.1002/hlca.19930760405

Reference yield: 74.0%

4-amino-1-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)dimethylsilyl>-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidine (151293-94-6) → 4-amino-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-1H-pyrazolo<3,4-d>pyrimidine (119898-95-2)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1002/hlca.19930760405

upstream raw materials:

4-amino-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo<3,4-d>pyrimidine

4-amino-1-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)dimethylsilyl>-β-D-glycero-pentofuranosyl>-1H-pyrazolo<3,4-d>pyrimidine

1-<2,3-dideoxy-5-O-<(1,1-dimethylethyl)dimethylsilyl>-β-D-glycero-pentofuranosyl>-4-methoxy-1H-pyrazolo<3,4-d>pyrimidine

4-benzoylamino-1-(2,3-dideoxy-β-D-glycero-pentofuranosyl)-5'-O-(4,4'-dimethoxytriphenylmethyl)-1H-pyrazolo<3,4-d>pyrimidine