2'-deoxyribofuranosyl-1-deazapurine

Base Information

• Chemical Name: 2'-deoxyribofuranosyl-1-deazapurine
• CAS No.: 125178-07-6
• Molecular Formula: C11H13 N3 O3
• Molecular Weight: 235.243
• Mol file: 125178-07-6.mol

Synonyms:2'-deoxyribofuranosyl-1-deazapurine

Chemical Property of 2'-deoxyribofuranosyl-1-deazapurine

Chemical Property:

• Boiling Point: 528.8°Cat760mmHg
• Flash Point: 273.6°C
• PSA: 80.40000
• Density: 1.61g/cm³
• LogP: 0.07200

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-deoxyribofuranosyl-1-deazapurine

There total 7 articles about 2'-deoxyribofuranosyl-1-deazapurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-<2-deoxy-3,5-di-O-(4-toluoyl)-β-D-erythro-pentofuranosyl>-3H-imidazo<4,5-b>pyridine → 3-<2-deoxy-β-D-erythro-pentofuranosyl>-3H-imidazo<4,5-b>pyridine (125178-07-6)

Guidance literature:

With ammonia; In methanol; for 36h; Ambient temperature;

DOI:10.1002/hlca.19960790117

Reference yield: 67.0%

5,7-dichloro-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3H-imidazo[4,5-b]pyridine (159944-82-8) → 3-<2-deoxy-β-D-erythro-pentofuranosyl>-3H-imidazo<4,5-b>pyridine (125178-07-6)

Guidance literature:

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; for 6h; under 3102.9 Torr;

DOI:10.1080/15257779408013282

Reference yield: 51.0%

2'-deoxyuridine (951-78-0,63844-76-8) + 3H-imidazo[4,5-b]pyridine (273-21-2) → 3-<2-deoxy-β-D-erythro-pentofuranosyl>-3H-imidazo<4,5-b>pyridine (125178-07-6)

Guidance literature:

at 37 ℃; for 7h; alginate gel-entrapped cells of auxotrophic thymine-dependent strain of E_. coli, ammonium acetate buffer pH 5.8;

DOI:10.1135/cccc19942303

upstream raw materials:

5,7-dichloro-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3H-imidazo[4,5-b]pyridine

2'-deoxyuridine

3H-imidazo[4,5-b]pyridine

2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

Downstream raw materials:

2-deoxy-D-ribose

1H-Imidazo[4,5-b]pyridine

Refernces

• 1、 Cristalli,Vittori,Eleuteri,Volpini,Camaioni,Lupidi. "Synthesis of 2'-deoxyribonucleoside derivatives of 1-deazapurine". . p. 835 - 848. Retrieved 1994.