4-Bromophenylacetyl chloride

Base Information

• Chemical Name: 4-Bromophenylacetyl chloride
• CAS No.: 37859-24-8
• Molecular Formula: C8H6BrClO
• Molecular Weight: 233.492
• Hs Code.: 2916399090
• Mol file: 37859-24-8.mol

Synonyms:(4-Bromophenyl)acetylchloride;(p-Bromophenyl)acetyl chloride;4-Bromobenzeneacetyl chloride;p-Bromophenylacetic acid chloride;4-Bromophenylacetic acid chloride;2-(4-bromophenyl)ethanoyl chloride;

Chemical Property of 4-Bromophenylacetyl chloride

Chemical Property:

• Appearance/Colour: liquid
• Vapor Pressure: 0.00296mmHg at 25°C
• Refractive Index: 1.572
• Boiling Point: 284.6 °C at 760 mmHg
• Flash Point: 125.9 °C
• PSA: 17.07000
• Density: 1.589 g/cm³
• LogP: 2.75700
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

(4-Bromophenyl)acetylChloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-22
• Safety Statements: 26-36/37/39-45

MSDS Files:

Useful:

Technology Process of 4-Bromophenylacetyl chloride

There total 5 articles about 4-Bromophenylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(4-bromophenyl)-acetic acid (1878-68-8) → 2-(4-bromophenyl)acetyl chloride (37859-24-8)

Guidance literature:

With thionyl chloride;

Reference yield:

(4-bromo-phenyl)-acetic acid methyl ester (41841-16-1) → 2-(4-bromophenyl)acetyl chloride (37859-24-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water; methanol; tetrahydrofuran / 12 h / 23 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 23 °C / Inert atmosphere; Cooling with ice

With oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;

DOI:10.1021/acs.joc.0c00494

Reference yield:

4-aminophenylacetic acid (1197-55-3) → 2-(4-bromophenyl)acetyl chloride (37859-24-8)

Guidance literature:

Multi-step reaction with 2 steps

2: thionyl chloride

With thionyl chloride;

upstream raw materials:

2-(4-bromophenyl)-acetic acid

4-aminophenylacetic acid

thionyl chloride

(4-bromo-phenyl)-acetic acid methyl ester

Downstream raw materials:

4'-bromo-2-hydroxy-3,4-dimethoxy-deoxybenzoin

4-bromobenzeneacetamide

2-(4-bromophenyl)-1-(4-methoxyphenyl)-1-ethanone

2-(4-bromophenyl)-N,N-diethylacetamide

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