2-chloro-6-(4-chlorophenyl)-3-(4-methylphenyl)-1-oxa-3-aza-2$l^{5}-pho sphacyclohex-5-ene 2-oxide

Base Information

• Chemical Name: 2-chloro-6-(4-chlorophenyl)-3-(4-methylphenyl)-1-oxa-3-aza-2$l^{5}-pho sphacyclohex-5-ene 2-oxide
• CAS No.: 91920-19-3
• Molecular Formula: C₁₆H₁₄Cl₂NO₂P
• Molecular Weight: 354.172
• Mol file: 91920-19-3.mol

Synonyms:NSC 359882

Chemical Property of 2-chloro-6-(4-chlorophenyl)-3-(4-methylphenyl)-1-oxa-3-aza-2$l^{5}-pho sphacyclohex-5-ene 2-oxide

Chemical Property:

• Vapor Pressure: 2.68E-09mmHg at 25°C
• Boiling Point: 478°Cat760mmHg
• Flash Point: 242.9°C
• PSA: 39.35000
• Density: 1.41g/cm³
• LogP: 5.93800

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-chloro-6-(4-chlorophenyl)-3-(4-methylphenyl)-1-oxa-3-aza-2$l^{5}-pho sphacyclohex-5-ene 2-oxide

There total 3 articles about 2-chloro-6-(4-chlorophenyl)-3-(4-methylphenyl)-1-oxa-3-aza-2$l^{5}-pho sphacyclohex-5-ene 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-chlorophenyl)-3-dimethylamino-propan-1-one hydrochloride (1798-83-0) → 2-Chloro-6-(4-chloro-phenyl)-3-p-tolyl-3,4-dihydro-[1,3,2]oxazaphosphinine 2-oxide (91920-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. ethanol / Heating; 2-3h

2: 1. POCl₃, 2. Et₃N / 1. CH₂Cl₂, RT, 24h

With triethylamine; trichlorophosphate; In ethanol;

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 2-Chloro-6-(4-chloro-phenyl)-3-p-tolyl-3,4-dihydro-[1,3,2]oxazaphosphinine 2-oxide (91920-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. ethanol / Heating; 2-3h

2: 1. POCl₃, 2. Et₃N / 1. CH₂Cl₂, RT, 24h

With triethylamine; trichlorophosphate; In ethanol;

Reference yield:

1-(4-Chloro-phenyl)-3-p-tolylamino-propan-1-one (135779-27-0) → 2-Chloro-6-(4-chloro-phenyl)-3-p-tolyl-3,4-dihydro-[1,3,2]oxazaphosphinine 2-oxide (91920-19-3)

Guidance literature:

With triethylamine; trichlorophosphate; Yield given. Multistep reaction; 1. CH₂Cl₂, RT, 24h;

upstream raw materials:

1-(4-Chloro-phenyl)-3-p-tolylamino-propan-1-one

1-(4-chlorophenyl)-3-dimethylamino-propan-1-one hydrochloride

p-toluidine