Technology Process of Hexahydrodifenidol
There total 3 articles about Hexahydrodifenidol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrahydrofuran; nickel;
at 80 ℃;
under 147102 Torr;
Hydrogenation;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium methylate; potassium hydroxide; tetrahydrofuran / Anschliessend mit Cyclohexyl-phenyl-keton behandeln.
2: Raney nickel; tetrahydrofuran / 80 °C / 147102 Torr / Hydrogenation
With
tetrahydrofuran; potassium hydroxide; sodium methylate; nickel;
- Guidance literature:
-
In
tetrahydrofuran; diethyl ether;
Yield given;
1. 16h room temperature, 2. 10hreflux;
DOI:10.1002/jlac.198519851112
