2,4-Dichloro-7-methoxy-3-phenylquinoline

Base Information

• Chemical Name: 2,4-Dichloro-7-methoxy-3-phenylquinoline
• CAS No.: 108832-16-2
• Molecular Formula: C16H11 Cl2 N O
• Molecular Weight: 304.175
• DSSTox Substance ID: DTXSID40353128
• Wikidata: Q82130577
• Mol file: 108832-16-2.mol

Synonyms:2,4-dichloro-7-methoxy-3-phenylquinoline;108832-16-2;Quinoline, 2,4-dichloro-7-methoxy-3-phenyl-;SCHEMBL4824018;DTXSID40353128;MFCD00101292;AKOS015963787;FT-0752304;2,4-dichloro-3-phenylquinolin-7-yl methyl ether;AE-406/41055831

Chemical Property of 2,4-Dichloro-7-methoxy-3-phenylquinoline

Chemical Property:

• Vapor Pressure: 3.27E-06mmHg at 25°C
• Boiling Point: 399°Cat760mmHg
• Flash Point: 195.1°C
• PSA: 22.12000
• Density: 1.322g/cm³
• LogP: 5.21720
• XLogP3: 5.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 303.0217694
• Heavy Atom Count: 20
• Complexity: 322

Purity/Quality:

2,4-dichloro-7-methoxy-3-phenylquinoline 95%-98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=C1)C(=C(C(=N2)Cl)C3=CC=CC=C3)Cl

Technology Process of 2,4-Dichloro-7-methoxy-3-phenylquinoline

There total 5 articles about 2,4-Dichloro-7-methoxy-3-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-hydroxy-7-methoxy-3-phenyl-2(1H)-quinolinone (28563-22-6) → 2,4-dichloro-7-methoxy-3-phenyl-quinoline (108832-16-2)

Guidance literature:

With trichlorophosphate; at 110 ℃; for 2h;

DOI:10.1021/jm040154f

Reference yield: 85.0%

1-ethyl-4-hydroxy-7-methoxy-3-phenyl-2(1H)-quinolone (125878-99-1) → 2,4-dichloro-7-methoxy-3-phenyl-quinoline (108832-16-2) + 4-chloro-1-ethyl-7-methoxy-3-phenyl-quinolin-2(1H)-one (138617-02-4)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

DOI:10.1007/BF00815924

Reference yield: 53.0%

4-hydroxy-7-methoxy-1-methyl-3-phenyl-2(1H)-quinolinone (125878-98-0) → 2,4-dichloro-7-methoxy-3-phenyl-quinoline (108832-16-2) + 4-chloro-7-methoxy-1-methyl-3-phenyl-quinolin-2(1H)-one (138617-01-3)

Guidance literature:

With trichlorophosphate; for 1h; Heating;

DOI:10.1007/BF00815924

upstream raw materials:

4-hydroxy-7-methoxy-3-phenyl-2(1H)-quinolinone

4-hydroxy-7-methoxy-1-methyl-3-phenyl-2(1H)-quinolinone

1-ethyl-4-hydroxy-7-methoxy-3-phenyl-2(1H)-quinolone

m-Anisidine

Downstream raw materials:

2-ethyl-3-phenyl-4-(4-bromophenyloxy)-7-methoxyquinoline

4-(3-bromo-phenoxy)-2-ethyl-7-methoxy-3-phenyl-quinoline

4-(4-bromo-phenoxy)-2-ethyl-3-phenyl-quinolin-7-ol

4-(4-bromo-phenoxy)-7-methoxy-2,3-diphenyl-quinoline

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