Piperidine, 1,1'-(1,4-phenylenedicarbonyl)bis-

Base Information

• Chemical Name: Piperidine, 1,1'-(1,4-phenylenedicarbonyl)bis-
• CAS No.: 15088-30-9
• Molecular Formula: C18H24 N2 O2
• Molecular Weight: 300.401
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40164635
• Nikkaji Number: J129.869K
• Wikidata: Q83033699
• ChEMBL ID: CHEMBL4946406
• Mol file: 15088-30-9.mol

Synonyms:Piperidine, 1,1'-(1,4-phenylenedicarbonyl)bis-;15088-30-9;Piperidine, 1,1'-terephthaloyldi-;[4-(piperidine-1-carbonyl)phenyl]-piperidin-1-ylmethanone;1,1'-[1,4-phenylenedi(carbonyl)]dipiperidine;TimTec1_000027;Oprea1_469707;Terephthalic acid, dipiperidide;SCHEMBL7132525;1,1'-Terephthaloylbispiperidine;CHEMBL4946406;DTXSID40164635;HMS1534B05;STK670463;AKOS003409196;NCGC00175545-01;EU-0050885;benzene-1,4-diylbis(piperidin-1-ylmethanone);1-[4-(1-Piperidinylcarbonyl)benzoyl]piperidine #;Piperidine, 1,1/'-(1,4-phenylenedicarbonyl)bis-;BRD-K47901417-001-01-4;[4-(Piperidine-1-carbonyl)-phenyl]-piperidin-1-yl-methanone

Chemical Property of Piperidine, 1,1'-(1,4-phenylenedicarbonyl)bis-

Chemical Property:

• Vapor Pressure: 2.22E-10mmHg at 25°C
• Boiling Point: 506.5°C at 760 mmHg
• Flash Point: 230.3°C
• PSA: 40.62000
• Density: 1.157g/cm³
• LogP: 2.81460
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 300.183778013
• Heavy Atom Count: 22
• Complexity: 352

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)C2=CC=C(C=C2)C(=O)N3CCCCC3

Technology Process of Piperidine, 1,1'-(1,4-phenylenedicarbonyl)bis-

There total 7 articles about Piperidine, 1,1'-(1,4-phenylenedicarbonyl)bis- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

piperidine (110-89-4) + terephthaloyl chloride (100-20-9) → 1,4-phenylenebis(piperidin-1-ylmethanone) (15088-30-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/om400951n

Reference yield: 55.0%

piperidine (110-89-4) + terephthalaldehyde, (623-27-8) → 1,4-phenylenebis(piperidin-1-ylmethanone) (15088-30-9) + 1-((4-formylphenyl)carbonyl)piperidine (80020-14-0) + 4-Carboxybenzaldehyde (619-66-9)

Guidance literature:

With potassium tetrachloroaurate(III); potassium carbonate; In water; acetonitrile; at 60 ℃; for 12h;

DOI:10.1039/c2cc17689k

Reference yield: 23.0%

piperidine (110-89-4) + terephthalic acid (100-21-0) → 1,4-phenylenebis(piperidin-1-ylmethanone) (15088-30-9) + 4-(piperidine-1-carbonyl)benzoic acid (210961-92-5)

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; for 1h;

DOI:10.1016/j.bmc.2021.116242

upstream raw materials:

piperidine

N,N'-terephthaloylbis(6-hexanelactam)

1,4-benzenedicarboxylic acid dimethyl ester

terephthalaldehyde,

Downstream raw materials:

1,4-bis(piperidin-1-ylmethyl)benzene

Refernces

• 1、 Xie, Weilong,Zhao, Mengdi,Cui, Chunming. "Cesium carbonate-catalyzed reduction of amides with hydrosilanes". . p. 7440 - 7444. Retrieved 2014/04/03.
• 2、 Jones,Ossowski,Kus. "Crystal structures of seven terephthaldiamide derivatives". . p. 914 - 921. Retrieved 2007/10/03.