ethyl 2-{5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy}propanoate

Base Information

• Chemical Name: ethyl 2-{5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy}propanoate
• CAS No.: 50594-49-5
• Molecular Formula: C₁₈H₁₅ClF₃NO₆
• Molecular Weight: 433.768
• Mol file: 50594-49-5.mol

Synonyms:

Chemical Property of ethyl 2-{5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy}propanoate

Chemical Property:

• Vapor Pressure: 2.21E-08mmHg at 25°C
• Boiling Point: 452.6°Cat760mmHg
• Flash Point: 227.5°C
• PSA: 90.58000
• Density: 1.393g/cm³
• LogP: 5.91290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2-{5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy}propanoate

There total 8 articles about ethyl 2-{5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrophenoxy}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-dichloro-4-(trifluoromethyl)benzene (328-84-7) → 2-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenoxy]-propionic acid ethyl ester (50594-49-5,143502-46-9,95181-53-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) KOH / 1.) DMSO, H₂O, toluene, 2.) 160 deg C, 16 h

2: 88.2 percent / 1 h / 100 °C

3: 50.5 percent / 70percent HNO₃, conc. H₂SO₄ / 1,2-dichloro-ethane / 2 h / 20 °C

4: 97 percent / K₂CO₃ / methanol / 1 h / Heating

5: K₂CO₃ / Heating

With potassium hydroxide; sulfuric acid; nitric acid; potassium carbonate; In methanol; 1,2-dichloro-ethane;

DOI:10.1515/znb-1980-0721

Reference yield:

3-(2'-chloro-4'-trifluoromethyl-phenoxy)-phenol (50594-76-8) → 2-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenoxy]-propionic acid ethyl ester (50594-49-5,143502-46-9,95181-53-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 88.2 percent / 1 h / 100 °C

2: 50.5 percent / 70percent HNO₃, conc. H₂SO₄ / 1,2-dichloro-ethane / 2 h / 20 °C

3: 97 percent / K₂CO₃ / methanol / 1 h / Heating

4: K₂CO₃ / Heating

With sulfuric acid; nitric acid; potassium carbonate; In methanol; 1,2-dichloro-ethane;

DOI:10.1515/znb-1980-0721

Reference yield:

2-Chlor-4-trifluormethyl-3'-acetoxy-4'-nitrodiphenylether (50594-44-0) → 2-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenoxy]-propionic acid ethyl ester (50594-49-5,143502-46-9,95181-53-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / K₂CO₃ / methanol / 1 h / Heating

2: K₂CO₃ / Heating

With potassium carbonate; In methanol;

DOI:10.1515/znb-1980-0721

upstream raw materials:

5-(o-chloro-p-trifluoromethyl-phenoxy)-2-nitrophenol

Ethyl 2-bromopropionate

1,2-dichloro-4-(trifluoromethyl)benzene

3-(2'-chloro-4'-trifluoromethyl-phenoxy)-phenol

Downstream raw materials:

2-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenoxy]-N,N-dimethyl-propionamide

2-[5-(2-Chloro-4-trifluoromethyl-phenoxy)-2-nitro-phenoxy]-N-methyl-propionamide

2-<5-(2'-Chlor-4'-trifluormethylphenoxy)-2-nitrophenoxy>-propionsaeureamid

2-[5-(o-chloro-p-trifluoromethyl-phenoxy)-2-nitrophenoxy]-propionic acid