Methyl Morpholinoacetate

Base Information

• Chemical Name: Methyl Morpholinoacetate
• CAS No.: 35855-10-8
• Molecular Formula: C7H13 N O3
• Molecular Weight: 159.185
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID40361465
• Nikkaji Number: J305.046G
• Wikidata: Q82143805
• ChEMBL ID: CHEMBL4288514
• Mol file: 35855-10-8.mol

Synonyms:Methyl Morpholinoacetate;35855-10-8;methyl 2-morpholinoacetate;methyl 2-morpholin-4-ylacetate;Methyl N-morpholinoacetate;Methyl 2-(Morpholin-4-yl)acetate;Methyl 4-morpholineacetate;morpholin-4-yl-acetic acid methyl ester;methyl morpholin-4-ylacetate;Morpholin-4-yl-acetic acid, methyl ester;methyl2-morpholinoacetate;SCHEMBL2826608;CHEMBL4288514;DTXSID40361465;METHYL 4-MORPHOLINOACETATE;Morpholinoacetic acid methyl ester;methyl-2-(4-morpholinyl)-acetate;MFCD00216973;AKOS002320224;MS-0220;METHYL2-(MORPHOLIN-4-YL)ACETATE;CS-0206057;FT-0639283;H10557;A823002;F1965-0001

Chemical Property of Methyl Morpholinoacetate

Chemical Property:

• Vapor Pressure: 0.146mmHg at 25°C
• Refractive Index: 1.4575-1.4595
• Boiling Point: 215.7°Cat760mmHg
• Flash Point: 84.2°C
• PSA: 38.77000
• Density: 1.089g/cm³
• LogP: -0.57050
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 159.08954328
• Heavy Atom Count: 11
• Complexity: 132

Purity/Quality:

97% ^*data from raw suppliers

Methyl Morpholinoacetate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 34
• Safety Statements: 45-36/37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)CN1CCOCC1
• Uses: Methyl Morpholinoacetate (cas# 35855-10-8) is a compound useful in organic synthesis.

Technology Process of Methyl Morpholinoacetate

There total 6 articles about Methyl Morpholinoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

morpholine (110-91-8,99108-56-2) + bromoacetic acid methyl ester (96-32-2) → methyl 2-morpholin-4-ylacetate (35855-10-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃; for 5h;

Reference yield: 85.0%

morpholine (110-91-8,99108-56-2) + methyl diazoacetate (6832-16-2) → methyl 2-morpholin-4-ylacetate (35855-10-8)

Guidance literature:

With tetrakis(acetato)chloridodiruthenium(II,III); In benzene; at 75 ℃; for 20.5h; regioselective reaction;

DOI:10.1134/S1070428010100039

Reference yield: 82.0%

(E)-4-(3-methylbut-1-en-1-yl)morpholine (91890-09-4) + bromoacetic acid methyl ester (96-32-2) → methyl 2-morpholin-4-ylacetate (35855-10-8) + 5-Methyl-3-morpholin-4-yl-hexanoic acid methyl ester

Guidance literature:

With indium; In tetrahydrofuran; for 17.5h; Yields of byproduct given; Ambient temperature;

DOI:10.1016/0040-4039(95)01241-9

upstream raw materials:

morpholine

bromoacetic acid methyl ester

(E)-4-(3-methylbut-1-en-1-yl)morpholine

methyl diazoacetate

Downstream raw materials:

2-(morpholin-4-yl)ethanol

perfluorodiethyl ether

2,2,3,3,5,5,6,6-Octafluoro-4-trifluoromethyl-morpholine

2,2-difluoro-2-(2,2,3,3,5,5,6,6-octafluoromorpholin-4-yl)acetyl fluoride