5-((2,4-Dimethoxyphenyl)methyl)-2,4-thiazolidinedione

Base Information

Chemical Name:5-((2,4-Dimethoxyphenyl)methyl)-2,4-thiazolidinedione
CAS No.:79525-07-8
Molecular Formula:C₁₂H₁₃NO₄S
Molecular Weight:267.306
Hs Code.:
DSSTox Substance ID:DTXSID201000572
ChEMBL ID:CHEMBL4104501

Synonyms:BRN 5558540;79525-07-8;CHEMBL4104501;5-((2,4-Dimethoxyphenyl)methyl)-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-((2,4-dimethoxyphenyl)methyl)-;SCHEMBL11158115;DTXSID201000572;BDBM50240910;LS-151317;5-[(2,4-Dimethoxyphenyl)methyl]-4-hydroxy-1,3-thiazol-2(5H)-one

Suppliers and Price of 5-((2,4-Dimethoxyphenyl)methyl)-2,4-thiazolidinedione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 5-((2,4-Dimethoxyphenyl)methyl)-2,4-thiazolidinedione

Chemical Property:

Vapor Pressure:1.61E-08mmHg at 25°C
Boiling Point:456.5°Cat760mmHg
Flash Point:229.9°C
Density:1.313g/cm³
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:267.05652907
Heavy Atom Count:18
Complexity:336

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)CC2C(=O)NC(=O)S2)OC

Technology Process of 5-((2,4-Dimethoxyphenyl)methyl)-2,4-thiazolidinedione

There total 5 articles about 5-((2,4-Dimethoxyphenyl)methyl)-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.73%

: 91570-11-5
5-[(2,4-dimethoxyphenyl)methylidene]-1,3-thiazolidine-2,4-dione

: 79525-07-8
5-[(2,4-dimethoxyphenyl)methyl]-1,3-thiazolidine-2,4-dione

Guidance literature:: With pyridine; lithium borohydride; In tetrahydrofuran; regiospecific reaction; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.7b00606

Reference yield:

: 613-45-6
2,4-Dimethoxybenzaldehyde

: 79525-07-8
5-[(2,4-dimethoxyphenyl)methyl]-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 4 steps

1: 92.9 percent / piperidine, benzoic acid / toluene / 4 h / Heating

2: H₂ / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

3: 74.2 percent / 60percent NaH, NCS / tetrahydrofuran / 0.5 h / Ambient temperature

With piperidine; N-chloro-succinimide; hydrogen; sodium hydride; benzoic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; toluene;
DOI:10.1248/cpb.31.560

Reference yield:

: 7324-86-9
ethyl 3-(2,4-dimethoxyphenyl)-2-ethoxycarbonyl-2-propenoate

: 79525-07-8
5-[(2,4-dimethoxyphenyl)methyl]-1,3-thiazolidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

2: 74.2 percent / 60percent NaH, NCS / tetrahydrofuran / 0.5 h / Ambient temperature

With N-chloro-succinimide; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1248/cpb.31.560