2-Amino-1-(piperidin-1-yl)ethanone hydrochloride

Base Information

• Chemical Name: 2-Amino-1-(piperidin-1-yl)ethanone hydrochloride
• CAS No.: 5437-48-9
• Molecular Formula: C7H15ClN2O
• Molecular Weight: 178.662
• Hs Code.: 2933399090
• European Community (EC) Number: 675-138-3
• NSC Number: 16126
• Mol file: 5437-48-9.mol

Synonyms:5437-48-9;2-Amino-1-(piperidin-1-yl)ethanone hydrochloride;2-amino-1-piperidin-1-yl-ethanone hcl;2-Amino-1-piperidin-1-yl-ethanone hydrochloride;MFCD07366743;2-Amino-1-(1-piperidinyl)-1-ethanone hydrochloride;2-amino-1-(piperidin-1-yl)ethan-1-one hydrochloride;2-amino-1-piperidin-1-ylethanone;hydrochloride;2-Amino-1-piperidin-1-ylethanone hydrochloride;2-Amino-1-piperidin-1-yl-ethanone x HCl;SCHEMBL5476123;OINZXLOVUKWACU-UHFFFAOYSA-N;AMY24711;NSC16126;NSC-16126;AKOS015847492;AKOS015894514;SB41390;2-Amino-1-(1-piperidinyl)-ethanone HCl;DS-13070;SY076125;A7903;CS-0186529;FT-0658366;2-amino-1-(piperidin-1-yl)ethan-1-one HCl;EN300-68165;2-Amino-1-(1-piperidyl)ethanone Hydrochloride;F21140;2-Amino-1-(piperidin-1-yl)ethanonehydrochloride;Z1263602390

Chemical Property of 2-Amino-1-(piperidin-1-yl)ethanone hydrochloride

Chemical Property:

• Appearance/Colour: Solid
• Vapor Pressure: 0.000422mmHg at 25°C
• Melting Point: 192-193oC
• Boiling Point: 311.2 °C at 760 mmHg
• Flash Point: 142 °C
• PSA: 46.33000
• LogP: 0.59580
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 178.0872908
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-1-(piperidin-1-yl)ethan-1-oneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(CC1)C(=O)CN.Cl

Technology Process of 2-Amino-1-(piperidin-1-yl)ethanone hydrochloride

There total 2 articles about 2-Amino-1-(piperidin-1-yl)ethanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-<((tert-butoxycarbonyl)amino)acetyl>piperidine (88621-47-0) → 2-amino-1-(piperidin-1-yl)ethan-1-one hydrochloride (5437-48-9)

Guidance literature:

With hydrogenchloride; In ethyl acetate; Ambient temperature;

DOI:10.1021/jm00119a015

Reference yield:

piperidine (110-89-4) → 2-amino-1-(piperidin-1-yl)ethan-1-one hydrochloride (5437-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / DCC / ethyl acetate

2: HCl / ethyl acetate / Ambient temperature

With hydrogenchloride; dicyclohexyl-carbodiimide; In ethyl acetate;

DOI:10.1021/jm00119a015

Reference yield: 93.0%

2-amino-1-(piperidin-1-yl)ethan-1-one hydrochloride (5437-48-9) + 2-chloro-5-(trifluoromethyl)pyrimidine (69034-12-4) → 1-(piperidin-1-yl)-2-((5-(trifluoromethyl)pyrimidin-2-yl)amino)ethanone

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 100 ℃; for 0.5h; Inert atmosphere;

DOI:10.1055/s-0036-1588425

upstream raw materials:

N-<((tert-butoxycarbonyl)amino)acetyl>piperidine

piperidine

Downstream raw materials:

1-[5-(4-methoxy-phenoxymethyl)-[1,2,3]thiadiazole-4-carbonyl]-piperidine

1-[5-(3,4-dichloro-phenoxymethyl)-[1,2,3]thiadiazole-4-carbonyl]-piperidine

1-(5-phenoxymethyl-[1,2,3]thiadiazole-4-carbonyl)-piperidine

1-[5-(4-chloro-phenoxymethyl)-[1,2,3]thiadiazole-4-carbonyl]-piperidine