L-Prolinamide, glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Base Information

Chemical Name:L-Prolinamide, glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
CAS No.:67341-40-6
Molecular Formula:C17H19N3O4
Molecular Weight:329.3505
Hs Code.:
DSSTox Substance ID:DTXSID70986605
Nikkaji Number:J1.966.207A
Wikidata:Q76009841
Mol file:67341-40-6.mol

Synonyms:Gly-Pro-4-methylcoumaryl-7-amide;Gly-Pro-MCA;glycylprolyl-4-methylcoumaryl-7-amide

Suppliers and Price of L-Prolinamide, glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of L-Prolinamide, glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

Chemical Property:

Vapor Pressure:2.52E-16mmHg at 25°C
Boiling Point:641°Cat760mmHg
Flash Point:341.4°C
PSA：105.64000
Density:1.378g/cm³
LogP:1.70080
XLogP3:0.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:329.13755610
Heavy Atom Count:24
Complexity:574

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C3CCCN3C(=O)CN
Isomeric SMILES:CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@@H]3CCCN3C(=O)CN

Technology Process of L-Prolinamide, glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-

There total 3 articles about L-Prolinamide, glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67341-41-7
C₂₂H₂₇N₃O₆

: 67341-40-6
7-glycyl-L-prolylamino-4-methylcoumarin

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1002/chem.201001077

Reference yield:

: 14296-92-5
(S)-1-(2-(tert-butoxycarbonylamino)acetyl)pyrrolidine-2-carboxylic acid

: 67341-40-6
7-glycyl-L-prolylamino-4-methylcoumarin

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201001077

Reference yield:

: 704-15-4
H-Gly-Pro-OH

: 67341-40-6
7-glycyl-L-prolylamino-4-methylcoumarin

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 4 h / 20 - 60 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 0 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/chem.201001077