Naphtho(2,1-b)furan, 4-methoxy-2-nitro-

Base Information

• Chemical Name: Naphtho(2,1-b)furan, 4-methoxy-2-nitro-
• CAS No.: 75965-72-9
• Molecular Formula: C₁₃H₉NO₄
• Molecular Weight: 243.219
• NSC Number: 329226
• UNII: GPQ8ZN3SWG
• DSSTox Substance ID: DTXSID60226860
• Nikkaji Number: J548.002G
• Wikidata: Q83106427
• Pharos Ligand ID: SJB7K7KZQZSL
• ChEMBL ID: CHEMBL7644
• Mol file: 75965-72-9.mol

Synonyms:75965-72-9;Naphtho(2,1-b)furan, 4-methoxy-2-nitro-;NSC329226;4-methoxy-2-nitronaphtho[2,1-b]furan;NSC-329226;2-Nitro-4-methoxynaphtho(2,1-b)furan;4-Methoxy-2-nitronaphtho(2,1-b)furan;2-Nitro-4-methoxynaphtho[2,1-b]furan;Naphtho[2,1-b]furan, 4-methoxy-2-nitro-;NSC 329226;Compound D15;starbld0026636;GPQ8ZN3SWG;NCIStruc1_000743;NCIStruc2_000701;CHEMBL7644;SCHEMBL8738468;BDBM22594;DTXSID60226860;CCG-37851;NCGC00014767;NCI329226;4-methoxy-2-nitro-benzo[e]benzofuran;1-methoxy-2-nitrobenzo[e][1]benzofuran;NCGC00014767-02;NCGC00097868-01;NCI60_002871;R-7100;hydroxy(4-methoxynaphtho[2,1-b]furan-2-yl)azane oxide;7-methoxy-4-nitro-5-oxatricyclo[7.4.0.0^{2,6}]trideca-1(13),2(6),3,7,9,11-hexaene

Chemical Property of Naphtho(2,1-b)furan, 4-methoxy-2-nitro-

Chemical Property:

• PSA: 68.19000
• LogP: 4.02600
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 243.05315777
• Heavy Atom Count: 18
• Complexity: 329

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=CC=CC=C2C3=C1OC(=C3)[N+](=O)[O-]

Technology Process of Naphtho(2,1-b)furan, 4-methoxy-2-nitro-

There total 3 articles about Naphtho(2,1-b)furan, 4-methoxy-2-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-2-naphthol (18515-11-2) → nitro-2 methoxy-4 naphto<2,1-b>furanne (75965-72-9,84720-74-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / TiCl₄ / CH₂Cl₂ / 2 h / 5 °C

2: benzene / Heating

3: benzene / 1.) 15 h, room temp., 2.) 1 h, reflux

With titanium tetrachloride; In dichloromethane; benzene;

Reference yield:

2-hydroxy-3-methoxynaphthalene-1-carbaldehyde (17133-82-3) → nitro-2 methoxy-4 naphto<2,1-b>furanne (75965-72-9,84720-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Heating

2: benzene / 1.) 15 h, room temp., 2.) 1 h, reflux

In benzene;

Reference yield:

bromonitromethane (563-70-2) + 1-(Di-morpholin-4-yl-methyl)-3-methoxy-naphthalen-2-ol → nitro-2 methoxy-4 naphto<2,1-b>furanne (75965-72-9,84720-74-1)

Guidance literature:

In benzene; Yield given; 1.) 15 h, room temp., 2.) 1 h, reflux;

upstream raw materials:

bromonitromethane

3-methoxy-2-naphthol

2-hydroxy-3-methoxynaphthalene-1-carbaldehyde