tert-butyl [(2S,3R)-4-({(2R,3S)-4-[3-(benzyloxy)phenyl]-3-[(tert-butoxycarbonyl)amino]-2-hydroxybutyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate

Base Information

Chemical Name:tert-butyl [(2S,3R)-4-({(2R,3S)-4-[3-(benzyloxy)phenyl]-3-[(tert-butoxycarbonyl)amino]-2-hydroxybutyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate
CAS No.:162538-23-0
Molecular Formula:C₃₇H₅₁N₃O₇
Molecular Weight:649.828
Hs Code.:
Mol file:162538-23-0.mol

tert-butyl [(2S,3R)-4-({(2R,3S)-4-[3-(benzyloxy)phenyl]-3-[(tert-butoxycarbonyl)amino]-2-hydroxybutyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate

Synonyms:

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Chemical Property of tert-butyl [(2S,3R)-4-({(2R,3S)-4-[3-(benzyloxy)phenyl]-3-[(tert-butoxycarbonyl)amino]-2-hydroxybutyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate

Chemical Property:

Vapor Pressure:6.25E-27mmHg at 25°C
Boiling Point:798.9°Cat760mmHg
Flash Point:437°C
Density:1.156g/cm³

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl [(2S,3R)-4-({(2R,3S)-4-[3-(benzyloxy)phenyl]-3-[(tert-butoxycarbonyl)amino]-2-hydroxybutyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate

There total 12 articles about tert-butyl [(2S,3R)-4-({(2R,3S)-4-[3-(benzyloxy)phenyl]-3-[(tert-butoxycarbonyl)amino]-2-hydroxybutyl}amino)-3-hydroxy-1-phenylbutan-2-yl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 162538-23-0
[(S)-1-(3-Benzyloxy-benzyl)-3-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 59 percent / ethanol / Ambient temperature

2: 81 percent / Cs₂CO₃ / dimethylformamide / Ambient temperature

3: 91 percent / 1N aq. LiOH / tetrahydrofuran / 1 h / Ambient temperature

4: 4-methylmorpholine / tetrahydrofuran

5: tetrahydrofuran; diethyl ether / 0 °C

6: HCl / dioxane / 0 °C

7: NaBH₄

8: KOH / ethanol

9: methanol / 50 °C

With 4-methyl-morpholine; hydrogenchloride; potassium hydroxide; lithium hydroxide; sodium tetrahydroborate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a

Reference yield:

: 587-33-7,775-06-4,2180-37-2,32140-49-1,29562-33-2
m-tyrosine

: 162538-23-0
[(S)-1-(3-Benzyloxy-benzyl)-3-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 59 percent / ethanol / Ambient temperature

2: 81 percent / Cs₂CO₃ / dimethylformamide / Ambient temperature

3: 91 percent / 1N aq. LiOH / tetrahydrofuran / 1 h / Ambient temperature

4: 4-methylmorpholine / tetrahydrofuran

5: tetrahydrofuran; diethyl ether / 0 °C

6: HCl / dioxane / 0 °C

7: NaBH₄

8: KOH / ethanol

9: methanol / 50 °C

With 4-methyl-morpholine; hydrogenchloride; potassium hydroxide; lithium hydroxide; sodium tetrahydroborate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm950717a

Reference yield:

: 220871-52-3
1(R,S)-<1'-(S)-<(tert-butyloxycarbonyl)amino>-2-phenylethyl>oxirane

: 162538-23-0
[(S)-1-(3-Benzyloxy-benzyl)-3-((S)-3-tert-butoxycarbonylamino-2-hydroxy-4-phenyl-butylamino)-2-hydroxy-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / NH₃, NH₄OH / ethanol / Ambient temperature

2: methanol / 50 °C

With ammonium hydroxide; In methanol; ethanol;
DOI:10.1021/jm950717a