5-Fluoroindole-2-carboxylic acid

Base Information

Chemical Name:5-Fluoroindole-2-carboxylic acid
CAS No.:399-76-8
Molecular Formula:C9H6FNO2
Molecular Weight:179.151
Hs Code.:29339900
European Community (EC) Number:206-919-5
UNII:LFV2Z936CQ
DSSTox Substance ID:DTXSID10192945
Nikkaji Number:J149.573I
Wikidata:Q27190893
ChEMBL ID:CHEMBL23507
Mol file:399-76-8.mol

Synonyms:5-fluoroindole-2-carboxylic acid

Suppliers and Price of 5-Fluoroindole-2-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
5-Fluoroindole-2-carboxylic acid
500mg
$ 45.00

TCI Chemical
5-Fluoroindole-2-carboxylic Acid >98.0%(HPLC)(T)
1g
$ 55.00

TCI Chemical
5-Fluoroindole-2-carboxylic Acid >98.0%(HPLC)(T)
5g
$ 184.00

SynQuest Laboratories
5-Fluoroindole-2-carboxylic acid 99%
25 g
$ 552.00

SynQuest Laboratories
5-Fluoroindole-2-carboxylic acid 99%
1 g
$ 40.00

SynQuest Laboratories
5-Fluoroindole-2-carboxylic acid 99%
5 g
$ 136.00

Sigma-Aldrich
5-Fluoroindole-2-carboxylic acid 99%
5g
$ 239.00

Matrix Scientific
5-Fluoro-1H-indole-2-carboxylic acid
25g
$ 188.00

Matrix Scientific
5-Fluoro-1H-indole-2-carboxylic acid
1g
$ 12.00

Matrix Scientific
5-Fluoro-1H-indole-2-carboxylic acid
5g
$ 47.00

Total 88 raw suppliers

Chemical Property of 5-Fluoroindole-2-carboxylic acid

Chemical Property:

Appearance/Colour:yellow-brown crystalline powder
Vapor Pressure:7.01E-08mmHg at 25°C
Melting Point:259 °C (dec.)(lit.)
Boiling Point:422.2 °C at 760 mmHg
PKA:4.27±0.30(Predicted)
Flash Point:209.1 °C
PSA：53.09000
Density:1.51 g/cm³
LogP:2.00520
Storage Temp.:0-6°C
Water Solubility.:Insoluble
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:179.03825660
Heavy Atom Count:13
Complexity:222

Purity/Quality:

99% ^*data from raw suppliers

5-Fluoroindole-2-carboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi; F
Hazard Codes:Xi,F
Statements: 36/37/38-15-10
Safety Statements: 26-37/39-43-36-7/8

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC2=C(C=C1F)C=C(N2)C(=O)O
Uses 5-Fluoroindole-2-carboxylic acid,is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals and Dyestuff. Reactant for the synthesis of:Fungicidal agentsAntitumor agents2,3-dioxygenase (IDO) inhibitorsFactor Xa inhibitorsEnantioselective D3 receptor antagonistsLigands for hFPRL1 (or ALXR) receptor in inflammationAntibacterial agentsInhibitors of hepatitis C virus NS3·4A protease

Technology Process of 5-Fluoroindole-2-carboxylic acid

There total 8 articles about 5-Fluoroindole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 348-36-7
ethyl 5-fluoro-1H-indole-2-carboxylate

: 399-76-8
5-fluoroindole-2-carboxylic acid

Guidance literature:: ethyl 5-fluoro-1H-indole-2-carboxylate; With sodium hydroxide; In methanol; water; for 1h; Reflux; Green chemistry;

With hydrogenchloride; In methanol; water; at 50 ℃; pH=3 - 4; Green chemistry;