4-[(2-Amino-6-chloropyrimidin-4-yl)amino]-2-(hydroxymethyl)cyclopentan-1-ol

Base Information

Chemical Name:4-[(2-Amino-6-chloropyrimidin-4-yl)amino]-2-(hydroxymethyl)cyclopentan-1-ol
CAS No.:91296-08-1
Molecular Formula:C₁₀H₁₅ClN₄O₂
Molecular Weight:258.708
Hs Code.:
NSC Number:143917
DSSTox Substance ID:DTXSID10301510

Synonyms:91296-08-1;4-((2-Amino-6-chloropyrimidin-4-yl)amino)-2-(hydroxymethyl)cyclopentanol;4-[(2-amino-6-chloropyrimidin-4-yl)amino]-2-(hydroxymethyl)cyclopentan-1-ol;NSC143917;DTXSID10301510;NSC-143917

Suppliers and Price of 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]-2-(hydroxymethyl)cyclopentan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]-2-(hydroxymethyl)cyclopentan-1-ol

Chemical Property:

Vapor Pressure:3.14E-14mmHg at 25°C
Boiling Point:578.6°Cat760mmHg
Flash Point:303.7°C
Density:1.522g/cm³
XLogP3:1.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:258.0883534
Heavy Atom Count:17
Complexity:259

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(CC(C1CO)O)NC2=CC(=NC(=N2)N)Cl

Technology Process of 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]-2-(hydroxymethyl)cyclopentan-1-ol

There total 2 articles about 4-[(2-Amino-6-chloropyrimidin-4-yl)amino]-2-(hydroxymethyl)cyclopentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 23722-89-6
(+/-)-(1α,2β,4α)-4-amino-2-hydroxycyclopentanemethanol

: 91296-08-1
(+/-)-(1α,2β,4α)-4-<(2-amino-6-chloro-4-pyrimidinyl)amino>-2-hydroxycyclopentanemethanol

Guidance literature:: With triethylamine; In butan-1-ol; for 72h; Heating;
DOI:10.1021/jm00377a007

Reference yield: 39.0%

: 56-05-3
2-Amino-4,6-dichloropyrimidine

: 23722-89-6
(+/-)-(1α,2β,4α)-4-amino-2-hydroxycyclopentanemethanol

: 91296-08-1
(+/-)-(1α,2β,4α)-4-<(2-amino-6-chloro-4-pyrimidinyl)amino>-2-hydroxycyclopentanemethanol

: (1R,2S,4S)-4-[Bis-(2-amino-6-chloro-pyrimidin-4-yl)-amino]-2-hydroxymethyl-cyclopentanol

Guidance literature:: With triethylamine; In butan-1-ol; for 72h; Heating;
DOI:10.1021/jm00377a007

Reference yield:

: 106-47-8
4-chloro-aniline

: 91296-08-1
(+/-)-(1α,2β,4α)-4-<(2-amino-6-chloro-4-pyrimidinyl)amino>-2-hydroxycyclopentanemethanol

: 91296-09-2
(+/-)-(1α,2β,4α)-4-<<2-amino-6-chloro-5-<(4-chlorophenyl)azo>-4-pyrimidinyl>amino>-2-hydroxycyclopentanemethanol

Guidance literature:: With hydrogenchloride; sodium acetate; acetic acid; sodium nitrite; Yield given. Multistep reaction; 2.) RT, overnight;
DOI:10.1021/jm00377a007