3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole

Base Information

• Chemical Name: 3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole
• CAS No.: 17403-03-1
• Molecular Formula: C14H16 N2
• Molecular Weight: 212.294
• Hs Code.: 2933990090
• Mol file: 17403-03-1.mol

Synonyms:Indole,3-(1,2,3,6-tetrahydro-1-methyl-4-pyridyl)- (8CI);3-(1-Methyl-1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole

Chemical Property of 3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole

Chemical Property:

• Vapor Pressure: 2.52E-06mmHg at 25°C
• Boiling Point: 391.1°Cat760mmHg
• Flash Point: 190.3°C
• PSA: 19.03000
• Density: 1.144g/cm³
• LogP: 2.82470

Purity/Quality:

98%min ^*data from raw suppliers

3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole

There total 4 articles about 3-(1-methyl-1,2,3,6-tetrahydropyrid-4-yl)indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-Methyl-4-piperidone (1445-73-4) + indole (120-72-9) → 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (17403-03-1)

Guidance literature:

With potassium hydroxide; In methanol; for 18h; Reflux;

Reference yield: 40.0%

1-Methyl-4-piperidone (1445-73-4) + indole (120-72-9) → 3,3'-(1-methyl-piperidine-4,4-diyl)-bis-indole (55556-55-3) + 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (17403-03-1)

Guidance literature:

In acetic acid; at 100 ℃; for 1h;

DOI:10.1016/0223-5234(87)90172-3

Reference yield:

indole (120-72-9) → 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole (17403-03-1)

Guidance literature:

upstream raw materials:

1-Methyl-4-piperidone

indole

Downstream raw materials:

3-methyl-1,2,3,4,5,6,7,8-octahydro-6-phenylpyrido<3,4-c>pyrrolo<3,4-a>carbazol-5,7-dione

3-Methyl-6-phenyl-1,2,3,4,4a,6,7,11c-octahydropyrido<3,4-b>pyrano<3,4-b>indole Hydrochloride

3-(1-methylpiperidin-4-yl)-1H-indole

Refernces

• 1、 -. "PIPERIDINE-INDOLE COMPOUNDS HAVING 5-HT6 AFFINITY". Page/Page column 13. . Retrieved 2010/11/28.
• 2、 Cole, Derek C.,Ellingboe, John W.,Lennox, William J.,Mazandarani, Hossein,Smith, Deborah L.,Stock, Joseph R.,Zhang, Guoming,Zhou, Ping,Schechter, Lee E.. "N1-arylsulfonyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole derivatives are potent and selective 5-HT6 receptor antagonists". . p. 379 - 383. Retrieved 2007/10/03.