Spiro[3H-indole-3,6'(4'aH)-[1H]pyrano[3,4-f]- indolizine]-4'-carboxylic acid,1,2,5',5'a,7',8',10',10'a-octahydro-6- methoxy-1'-methyl-2-oxo-,methyl ester,(1'S,4'aS,5'aS,10'aS)-[partial]-

Base Information

• Chemical Name: Spiro[3H-indole-3,6'(4'aH)-[1H]pyrano[3,4-f]- indolizine]-4'-carboxylic acid,1,2,5',5'a,7',8',10',10'a-octahydro-6- methoxy-1'-methyl-2-oxo-,methyl ester,(1'S,4'aS,5'aS,10'aS)-[partial]-
• CAS No.: 13483-85-7
• Molecular Formula: C₂₂H₂₆N₂O₅
• Molecular Weight: 398.459
• Mol file: 13483-85-7.mol

Synonyms:

Chemical Property of Spiro[3H-indole-3,6'(4'aH)-[1H]pyrano[3,4-f]- indolizine]-4'-carboxylic acid,1,2,5',5'a,7',8',10',10'a-octahydro-6- methoxy-1'-methyl-2-oxo-,methyl ester,(1'S,4'aS,5'aS,10'aS)-[partial]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Spiro[3H-indole-3,6'(4'aH)-[1H]pyrano[3,4-f]- indolizine]-4'-carboxylic acid,1,2,5',5'a,7',8',10',10'a-octahydro-6- methoxy-1'-methyl-2-oxo-,methyl ester,(1'S,4'aS,5'aS,10'aS)-[partial]-

There total 4 articles about Spiro[3H-indole-3,6'(4'aH)-[1H]pyrano[3,4-f]- indolizine]-4'-carboxylic acid,1,2,5',5'a,7',8',10',10'a-octahydro-6- methoxy-1'-methyl-2-oxo-,methyl ester,(1'S,4'aS,5'aS,10'aS)-[partial]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-acetoxy-11-methoxy-19α-methyl-(7ξ,20α)-7H-18-oxa-yohimb-16-ene-16-carboxylic acid methyl ester (13281-23-7) → reserpinine oxindole (3382-38-5,3489-06-3,13483-85-7,19775-58-7,53851-13-1,61665-08-5,62358-35-4,62358-36-5)

Guidance literature:

With acetic acid; In methanol; water;

DOI:10.1007/BF00564092

Reference yield:

reserpinine (482-96-2) → reserpinine oxindole (3382-38-5,3489-06-3,13483-85-7,19775-58-7,53851-13-1,61665-08-5,62358-35-4,62358-36-5)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂

2: AcOH / methanol; H₂O

With acetic acid; In methanol; dichloromethane; water;

DOI:10.1007/BF00564092

Reference yield:

11-methoxy-19α-methyl-2-oxo-(7ξC2,20α)-formosanane-16-carboxylic acid methyl ester (3382-38-5,3489-06-3,13483-85-7,19775-58-7,53851-13-1,61665-08-5,62358-35-4,62358-36-5) → reserpinine oxindole (3382-38-5,3489-06-3,13483-85-7,19775-58-7,53851-13-1,61665-08-5,62358-35-4,62358-36-5)

Guidance literature:

In pyridine; (heating);

DOI:10.1007/BF00568031

upstream raw materials:

11-methoxy-19α-methyl-2-oxo-(7ξC²,20α)-formosanane-16-carboxylic acid methyl ester

7-acetoxy-11-methoxy-19α-methyl-(7ξ,20α)-7H-18-oxa-yohimb-16-ene-16-carboxylic acid methyl ester

reserpinine

Downstream raw materials:

reserpinine oxindole

reserpinine