Isosuccinimide

Base Information

• Chemical Name: Isosuccinimide
• CAS No.: 34085-09-1
• Molecular Formula: C4H5NO2
• Molecular Weight: 99.0892
• Hs Code.: 2933990090
• Mol file: 34085-09-1.mol

Synonyms:5-hydroxy-1,5-dihydropyrrol-2-one;4-hydroxy-2-butene lactam;5-Hydroxy-1,5-dihydro-pyrrol-2-on;5-hydroxy-3-pyrrolin-2-one;1,5-dihydro-5-hydroxy-2H-pyrrol-2-one;ISOSUCCINIMIDE;

Chemical Property of Isosuccinimide

Chemical Property:

• Boiling Point: 426.4±45.0 °C(Predicted)
• PSA: 49.66000
• Density: 1.385±0.06 g/cm3(Predicted)
• LogP: -0.44520

Purity/Quality:

98.5% ^*data from raw suppliers

1,5-dihydro-5-hydroxy-2H-Pyrrol-2-one 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Isosuccinimide

There total 8 articles about Isosuccinimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

maleiimide (541-59-3,25721-74-8) → 1,5-dihydro-5-hydroxy-2H-pyrrol-2-one (34085-09-1)

Guidance literature:

With sodium tetrahydroborate; cerium(III) chloride; In methanol; at 0 - 20 ℃; for 0.5h;

DOI:10.1039/b200729k

Reference yield:

maleiimide (541-59-3,25721-74-8) → Succinimide (123-56-8,89963-74-6) + 1,5-dihydro-5-hydroxy-2H-pyrrol-2-one (34085-09-1)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at -40 - -30 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

Reference yield:

acetic acid 5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester (171292-10-7) → 1,5-dihydro-5-hydroxy-2H-pyrrol-2-one (34085-09-1)

Guidance literature:

With lipase B of Candida antarctica; In hexane; tert-butyl alcohol; at 20 ℃; for 20h;

DOI:10.1021/jo991062e

upstream raw materials:

pyrrole

maleiimide

5-methoxyfuran-2(5H)-one

acetic acid 5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester

Downstream raw materials:

acetic acid 1-acetyl-5-oxo-2,5-dihydro-1H-pyrrol-2-yl ester