Acamprosate calcium

Base Information

• Chemical Name: Acamprosate calcium
• CAS No.: 77337-73-6
• Molecular Formula: C10H20CaN2O8S2
• Molecular Weight: 400.48
• Hs Code.: 29241990
• Mol file: 77337-73-6.mol

Synonyms:Acamprosatecalcium;Alcomed;Aotal;Ca-AOTA;Calcium N-acetylhomotaurinate;Calcium bisacetylhomotaurine;Campral EC;Sobriol;

Chemical Property of Acamprosate calcium

Chemical Property:

• Appearance/Colour: white, odorless or nearly odorless powder
• Melting Point: >300 °C
• PSA: 189.36000
• LogP: 1.05900
• Storage Temp.: Room temp
• Solubility.: H2O: >5mg/mL

Purity/Quality:

99% ^*data from raw suppliers

Acamprosate calcium ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Acamprosate is an acetylated derivative of the GABA analog homotaurine (tramiprosate; ). Despite its structural similarity to GABA, acamprosate does not act at GABAA receptors but does decrease paired-pulse inhibition of GABAA inhibitory post-synaptic currents (IPSCs) at short inter-stimulus intervals when used at a concentration of 300 μM, indicating that it may inhibit GABAB autoreceptor-mediated inhibition of GABA release. It is an NMDA receptor modulator with antagonist or agonist effects depending on brain region, receptor subunit composition, and other factors. Acamprosate (0.26 and 0.52 mmol/kg per day, i.p.) reduces voluntary intake of ethanol in rats, an effect that can be blocked by the GABA antagonist bicuculline . Formulations containing acamprosate have been used for the maintenance of alcohol abstinence.
• Uses: Of interest for the treatment of alcoholism. Store at -20°C Of interest for the treatment of alcoholism and other neurochemical disorders. Acamprosate calcium is a synthetic amino acid and a neurotransmitter analogue that is used as an alcohol deterrent in management of alcohol dependence and abuse. Acamprosate calcium was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004.
• Clinical Use: Maintenance of abstinence in alcohol dependence
• Drug interactions: Potentially hazardous interactions with other drugs None known