3-quinuclidinyl atrolactate

Base Information

• Chemical Name: 3-quinuclidinyl atrolactate
• CAS No.: 107757-79-9
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348
• Mol file: 107757-79-9.mol

Synonyms:(R)-QNA;3-Quinuclidinyl atrolactate; Atrolactic acid 3-quinuclidinyl ester

Chemical Property of 3-quinuclidinyl atrolactate

Chemical Property:

• Vapor Pressure: 1.85E-07mmHg at 25°C
• Boiling Point: 410°Cat760mmHg
• Flash Point: 201.8°C
• PSA: 49.77000
• Density: 1.22g/cm³
• LogP: 1.46940

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-quinuclidinyl atrolactate

There total 4 articles about 3-quinuclidinyl atrolactate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-ethyl 2-hydroxy-2-phenylpropanoate (29916-14-1,32122-08-0,76496-51-0,2406-23-7) + (S)-quinuclidin-3-ol (3684-26-2,25333-42-0,34583-34-1,1619-34-7) → (S)-2-Hydroxy-2-phenyl-propionic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (107757-79-9)

Guidance literature:

With sodium; Multistep reaction; 1) benzene, 30 min, reflux; 2) benzene, reflux, 30 min;

DOI:10.1021/jm00402a035

Reference yield:

(R)-ethyl 2-hydroxy-2-phenylpropanoate (2406-23-7,32122-08-0,76496-51-0,29916-14-1) + (S)-quinuclidin-3-ol (3684-26-2,25333-42-0,34583-34-1,1619-34-7) → (R)-2-Hydroxy-2-phenyl-propionic acid (S)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (107757-79-9)

Guidance literature:

With sodium; Multistep reaction; 1) benzene, 30 min, reflux; 2) benzene, reflux, 30 min;

DOI:10.1021/jm00402a035

Reference yield:

(S)-ethyl 2-hydroxy-2-phenylpropanoate (29916-14-1,32122-08-0,76496-51-0,2406-23-7) + (R)-quinuclidin-3-ol (25333-42-0) → (S)-2-Hydroxy-2-phenyl-propionic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester (107757-79-9)

Guidance literature:

With sodium; Multistep reaction; 1) benzene, 30 min, reflux; 2) benzene, reflux, 30 min;

DOI:10.1021/jm00402a035

upstream raw materials:

(S)-ethyl 2-hydroxy-2-phenylpropanoate

(S)-quinuclidin-3-ol

(R)-quinuclidin-3-ol

(R)-ethyl 2-hydroxy-2-phenylpropanoate

Refernces