Lovastatin acid

Base Information

Chemical Name:Lovastatin acid
CAS No.:75225-51-3
Deprecated CAS:76556-02-0,77285-87-1,77285-87-1
Molecular Formula:C₂₄H₃₈O₆
Molecular Weight:422.562
Hs Code.:
UNII:5CLV35Y90C
DSSTox Substance ID:DTXSID20873334
Nikkaji Number:J399.042G
Wikidata:Q24063271
NCI Thesaurus Code:C77442
Metabolomics Workbench ID:148274
ChEMBL ID:CHEMBL1201373
Mol file:75225-51-3.mol

Synonyms:L 154819;L-154,819;L-154819;lovestatin acid;mevinolinic acid;mevinolinic acid, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta(R*),8aalpha))-isomer;mevinolinic acid, aluminum salt (3:1);mevinolinic acid, calcium salt (2:1);mevinolinic acid, monoammonium salt, 1S-(1alpha(betaS*),2alpha,6beta,8beta(R*),8aalpha)-isomer;mevinolinic acid, monosodium salt;mevinolinic acid, monosodium salt, (1S-(1alpha(betaS*,deltaS*),2alpha,6beta,8beta(R*),8aalpha))-isomer

Suppliers and Price of Lovastatin acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Lovastatin Hydroxy Acid, Sodium Salt
10mg
$ 418.00

American Custom Chemicals Corporation
LOVASTATIN SODIUM 95.00%
1MG
$ 140.70

Total 14 raw suppliers

Chemical Property of Lovastatin acid

Chemical Property:

Vapor Pressure:5.09E-17mmHg at 25°C
Melting Point:140 - 143oC
Boiling Point:602.3°Cat760mmHg
PKA:4.31±0.10(Predicted)
Flash Point:199.1°C
PSA：106.89000
Density:1.14g/cm³
LogP:2.38090
Storage Temp.:Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
XLogP3:3.5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:11
Exact Mass:422.26683893
Heavy Atom Count:30
Complexity:654

Purity/Quality:

99% ^*data from raw suppliers

Lovastatin Hydroxy Acid, Sodium Salt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC(CC(CC(=O)O)O)O)C
Isomeric SMILES:CC[C@H](C)C(=O)O[C@H]1C[C@H](C=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@H](C[C@H](CC(=O)O)O)O)C

Technology Process of Lovastatin acid

There total 6 articles about Lovastatin acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75330-75-5,79952-44-6
lovastatin

: 75225-51-3,137767-34-1,76556-02-0,77285-87-1
lovastatin acid

: 151006-15-4,79952-42-4,76343-78-7,81739-25-5
(4R,6R)-4-hydroxy-6-(2-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)ethyl)tetrahydro-2H-pyran-2-one

: 132748-10-8
(3R,5R)-3,5-dihydroxy-7-((1S,2S,6R,8S,8aR)-8-hydroxy-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)heptanoic acid

Guidance literature:: lovastatin; With methanol; sodium hydroxide; 2,6-di-tert-butyl-4-methyl-phenol; at 50 ℃; for 1h;

With methanol; ammonia; water; lovastatin esterase; at 40 ℃; for 43h; pH=9.5;

With hydrogenchloride; In methanol; water; at 12 ℃; pH=2.5;