3,4-Dimethoxycinnamohydroxamic acid

Base Information

• Chemical Name: 3,4-Dimethoxycinnamohydroxamic acid
• CAS No.: 25356-83-6
• Molecular Formula: C11H13 N O4
• Molecular Weight: 223.229
• Hs Code.: 2924299090
• Nikkaji Number: J48.468G
• Wikidata: Q76325544
• Mol file: 25356-83-6.mol

Synonyms:3,4-Dimethoxycinnamohydroxamic acid;BRN 2655579;25356-83-6;CINNAMOHYDROXAMIC ACID, 3,4-DIMETHOXY-;3-(3,4-Dimethoxyphenyl)-2-propenehydroximic acid;3-(3,4-dimethoxyphenyl)-N-hydroxyprop-2-enamide;2-Propenamide, 3-(3,4-dimethoxyphenyl)-N-hydroxy-;AKOS005282999;LS-54201

Chemical Property of 3,4-Dimethoxycinnamohydroxamic acid

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 71.28000
• Density: 1.227g/cm³
• LogP: 2.06270
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 223.08445790
• Heavy Atom Count: 16
• Complexity: 254

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C=CC(=O)NO)OC
• Isomeric SMILES: COC1=C(C=C(C=C1)/C=C/C(=O)NO)OC

Technology Process of 3,4-Dimethoxycinnamohydroxamic acid

There total 3 articles about 3,4-Dimethoxycinnamohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

→ 3,4-dimethoxycinnamohydroxamic acid (25356-83-6)

Guidance literature:

Reference yield:

3,4-dimethoxy-cinnamoyl chloride (39856-08-1) → 3,4-dimethoxycinnamohydroxamic acid (25356-83-6)

Guidance literature:

With hydroxylamine hydrochloride; triethylamine; In chloroform; for 1h; Yield given; Ambient temperature;

DOI:10.1248/cpb.31.2810

Reference yield:

3,4-dimethoxycinnamic acid (2316-26-9) → 3,4-dimethoxycinnamohydroxamic acid (25356-83-6)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃ / 1 h / Heating

2: hydroxylamine hydrochloride/triethylamine / CHCl₃ / 1 h / Ambient temperature

With thionyl chloride; hydroxylamine hydrochloride; triethylamine; In chloroform;

DOI:10.1248/cpb.31.2810

upstream raw materials:

3,4-dimethoxy-cinnamoyl chloride

3,4-dimethoxycinnamic acid

Downstream raw materials:

3-(3,4-dimethoxyphenyl)propanoyl hydroxamic acid