Base Information
- Chemical Name:Cyanate
- CAS No.:661-20-1
- Molecular Formula:CNO-
- Molecular Weight:42.0173
- Hs Code.:
- Mol file:661-20-1.mol
Synonyms:
Synonyms:
The research focuses on the development of new water-soluble diamine complexes as catalysts for the hydrogenation of ketones under hydrogen pressure. The purpose of this study was to synthesize reusable catalytic systems that could be easily separated from reaction products, addressing the issue of catalyst recovery and recycling in homogeneously catalyzed chemical processes involving expensive transition metal complexes. The researchers successfully synthesized water-soluble rhodium and iridium complexes functionalized with PO3Na2 groups, which showed remarkable catalytic activities in the reduction of various ketones in basic aqueous media. The key chemicals used in the process included 2,2'-bipyridines, C2-symmetric diamines, sodium phosphonate, and the precursors 1 and 2, which were further reacted with functionalized isocyanates to form the catalytic species. The study concluded that these water-soluble complexes, particularly those based on ligand 2, exhibited high catalytic activity and could be recycled with minimal loss of activity, making them promising candidates for sustainable and efficient catalytic processes.
The research focuses on the synthesis and characterization of zirconium complexes supported by multidentate aminophenolato ligands, with the aim of investigating their catalytic activities in hydrophosphination reactions of alkenes and heterocumulenes. The study compares the performance of neutral zirconium complexes with their cationic derivatives, revealing that the neutral complex 1, bearing a multidentate amino mono(phenolato) ligand, exhibits high activity in the hydrophosphination of simple alkenes, yielding anti-Markovnikov products in 37?94% yields at room temperature. In contrast, cationic species generated from complex 3, stabilized by a bis(phenolato) ligand, show superior activity in the hydrophosphination of heterocumulenes, such as carbodiimides and isocyanates, producing phosphaguanidines and phosphaureas in 67?93% yields. The research concludes that the modification of ligand structures significantly influences the Lewis acidity and coordination space of metal centers, thereby affecting the catalytic activity of these complexes, which are among the most active group 4 metal-based catalysts for hydrophosphination reactions.
The study presents the development of a series of platinum(IV) prodrugs, specifically designed to enhance interaction with human serum albumin (HSA) for drug delivery purposes. The prodrugs were synthesized by asymmetrically functionalizing the axial ligands to mimic the features of a fatty acid, with the aim of improving cellular uptake and cytotoxicity. The lead compound, 4e, which has a hexadecyl chain, demonstrated a significant therapeutic potential due to its ability to form a tight, non-covalent complex with HSA (complex 7), enhancing its stability in blood and reducing the rate of reduction by ascorbate. The study involved platinum(IV) complexes with varying aliphatic tail lengths, including 4a, 4b, 4c, 4d, and 4e, which were used to investigate the impact of lipophilicity on cellular uptake and cytotoxicity. Other chemicals used included cisplatin as a reference compound, succinic anhydride, isocyanate reagents for the synthesis of the prodrugs, and ascorbate as a biological reductant to study the reduction of the Pt(IV) prodrugs. The purpose of these chemicals was to create a novel class of anticancer prodrugs with improved properties, such as enhanced stability, reduced side effects, and potentially increased efficacy.
The research aims to develop a new approach for the construction of quaternary stereogenic centers bearing nitrogen substituents in an enantioselective manner. The strategy leverages the [1,3]-chirality transfer from a chiral primary alcohol equivalent through an allyl cyanate-to-isocyanate rearrangement. The efficiency of this approach was demonstrated in the eight-step synthesis of the marine natural product (+)-geranyllinaloisocyanide, achieving an overall yield of 43%. Key chemicals used in the process include chiral primary alcohol equivalent, allyl cyanate, isocyanate, and various reagents such as diethylzinc, trichloroacetyl isocyanate, potassium carbonate, trifluoroacetic anhydride, N,N-diisopropylethylamine, lithium triethylborohydride, and cesium fluoride, among others. The study concluded that the allyl cyanate-to-isocyanate rearrangement with enantiomerically enriched α-silyl allyl alcohol is a highly effective method for chirality transfer, showcasing its potential for further applications in the synthesis of nitrogen-containing natural products.
The research focused on the optimization, design, and synthesis of T-type calcium channel blockers, specifically spiropiperidine azetidines and azetidinones, with the goal of treating inflammatory and neuropathic pain. The research involved a series of experiments to evaluate and optimize the potency, selectivity, and drug metabolism and pharmacokinetic (DMPK) properties of these blockers targeting CaV3.2 channels. The experiments utilized a modular synthetic approach to explore structure-activity relationships (SAR) using a variety of reactants, including esters, aldimines, and isocyanates. Analytical techniques such as IonWorks HT, manual patch clamp analysis, and whole-cell patch clamp analysis were used to evaluate the activity and selectivity of the synthesized compounds. The research also endeavored to improve DMPK properties and TRPV1 selectivity through structural modifications, and in vivo evaluations were performed using a rat spinal nerve ligation model to assess the efficacy of the compounds in treating neuropathic pain. Although the compounds showed good in vitro activity, they did not show statistically significant effects in in vivo models, which was attributed to high protein binding and the need for higher in vivo exposures to effectively block CaV3.2 channels.
The research aimed to explore the Diels-Alder cycloaddition reaction involving unactivated 2-aza-1,3-dienes with electron-poor dienophiles, such as dialkyl azodicarboxylates and heterocumulenes. This study was significant as it provided the first example of such a reaction with electronically neutral 2-azadienes, challenging the previous notion that these azadienes required electron-donating substituents to react with electron-poor dienophiles. The researchers successfully demonstrated that 2-azadienes could participate in [4+2] cycloadditions with simple aldehydes and carbon disulfide, yielding products like 1,2,3,6-tetrahydro-1,2,4-triazines and 1,2-dihydropyrimidin-4(3H)-ones, among others. The study concluded that unactivated 2-aza-1,3-dienes have potential in cycloaddition reactions, particularly with electron-poor dienophiles, showcasing a high yield and selectivity in the reactions. Key chemicals used in the process included 2-azadienes of type (1), dialkyl azodicarboxylates (3), isocyanates (5), isothiocyanates, and carbon disulfide (5) with catalytic amounts of BF3.Et2O.
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