2-(5-Methylthien-3-yl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one

Base Information

Chemical Name:2-(5-Methylthien-3-yl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one
CAS No.:104679-67-6
Molecular Formula:C₁₅H₁₁N₃OS
Molecular Weight:281.338
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20909122
Nikkaji Number:J435.121E
Wikidata:Q82878670
ChEMBL ID:CHEMBL3144843
Mol file:104679-67-6.mol

Synonyms:2-(5-methylthien-3-yl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one;S 135;S-135

Suppliers and Price of 2-(5-Methylthien-3-yl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(5-Methylthien-3-yl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one

Chemical Property:

Vapor Pressure:3.79E-10mmHg at 25°C
Boiling Point:500.5°Cat760mmHg
Flash Point:256.5°C
PSA：78.92000
Density:1.41g/cm³
LogP:3.23690
XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:281.06228316
Heavy Atom Count:20
Complexity:405

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=CS1)N2C(=O)C3=C(N2)C4=CC=CC=C4N=C3

Technology Process of 2-(5-Methylthien-3-yl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one

There total 5 articles about 2-(5-Methylthien-3-yl)-2,5-dihydro-3H-pyrazolo(4,3-c)quinolin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 104635-86-1
2-(2-carboxy-5-methylthien-3-yl)-2,5-dihydro-3H-pyrazolo<4,3-c>quinolin-3-one

: 104679-67-6
2-(5-methylthien-3-yl)-2,5-dihydro-3H-pyrazolo<4,3-c>quinolin-3-one

Guidance literature:: With copper; In quinoline; at 190 ℃; for 1h;
DOI:10.1021/jm00117a012

Reference yield:

: 13720-94-0
ethyl 4-chloroquinoline-3-carboxylate

: 104679-67-6
2-(5-methylthien-3-yl)-2,5-dihydro-3H-pyrazolo<4,3-c>quinolin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / ethanol / 1.5 h / Ambient temperature

2: 97 percent / 1 N aq. sodium hydroxide / ethanol / Ambient temperature

3: 96 percent / 1 N aq. sodium hydroxide / ethanol / 1 h / Heating

4: 86 percent / copper / quinoline / 1 h / 190 °C

With sodium hydroxide; copper; In quinoline; ethanol;
DOI:10.1021/jm00117a012

Reference yield:

: 75681-14-0
methyl 3-hydrazino-5-methylthiophene-2-carboxylate

: 104679-67-6
2-(5-methylthien-3-yl)-2,5-dihydro-3H-pyrazolo<4,3-c>quinolin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / ethanol / 1.5 h / Ambient temperature

2: 97 percent / 1 N aq. sodium hydroxide / ethanol / Ambient temperature

3: 96 percent / 1 N aq. sodium hydroxide / ethanol / 1 h / Heating

4: 86 percent / copper / quinoline / 1 h / 190 °C

With sodium hydroxide; copper; In quinoline; ethanol;
DOI:10.1021/jm00117a012