7-{(3S)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Base Information

• Chemical Name: 7-{(3S)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
• CAS No.: 146981-10-4
• Molecular Formula: C₁₈H₂₁FN₄O₃
• Molecular Weight: 360.388
• Mol file: 146981-10-4.mol

Synonyms:

Chemical Property of 7-{(3S)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 6.36E-15mmHg at 25°C
• Boiling Point: 593.3°Cat760mmHg
• Flash Point: 312.6°C
• Density: 1.467g/cm³

Purity/Quality:

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Technology Process of 7-{(3S)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

There total 23 articles about 7-{(3S)-3-[(1S)-1-aminoethyl]pyrrolidin-1-yl}-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-[1-(N-tert-butoxycarbonylamino)ethyl]pyrrolidine (107258-90-2) → 3R,1S-7-[3-(1-aminoethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (135026-90-3,146981-10-4)

Guidance literature:

With dimethyl sulfoxide; trifluoroacetic acid; In hexane; water; methoxybenzene;

Reference yield:

gold (7440-57-5,457905-15-6) + 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid (100361-18-0) → 3R,1S-7-[3-(1-aminoethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (135026-90-3,146981-10-4) + 7-[3-(1-Aminoethyl)-1-pvrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8 -naphthyridine-3-carboxylic Acid

Guidance literature:

With hydrogenchloride; triethylamine; In ethanol; water; acetonitrile;

Reference yield:

3-[1-(N-tert-butoxycarbonylamino)ethyl]pyrrolidine (107258-90-2) + 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid (100361-18-0) → 3R,1S-7-[3-(1-aminoethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid (135026-90-3,146981-10-4)

Guidance literature:

With hydrogenchloride; triethylamine; In ethanol; acetonitrile;

upstream raw materials:

3R,1S-1-cyclopropyl-6-fluoro-7-[3-(1-N-t-butyloxycarbonylaminoethyl)-1-pyrrolidinyl]-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid

4-acetyl-1-benzyl-2-pyrrolidinone

ethyl [L-(trans)]-4-[(t-butoxycarbonyl)amino]-2-pentenoate

ethyl (3RS,4S)-4-(tert-butoxycarbonylamino)-3-hydroxypentanoate

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